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FLASH GENE
Symbol MARCH6 contributors: npt - updated : 17-03-2010
HGNC name membrane-associated ring finger (C3HC4) 6
HGNC id 30550
Location 5p15.2      Physical location : 10.353.827 - 10.435.491
Synonym name
  • Doa10 homolog
  • membrane-associated RING-CH protein VI
  • protein TEB-4
  • RING finger protein 176
  • Doa10 homolog
  • Synonym symbol(s) TEB4, RNF176, KIAA0597, MARCH-VI
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 81.66 kb     26 Exon(s)
    MAPPING cloned Y linked N status
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 4611 - 910 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Reproductivefemale systemovary  moderately
     female systemuteruscervix highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscular    
    cell lineage
    cell lines
    fluid/secretion blood
    at STAGE
    physiological period fetal
    Text pancreas predominantly
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus RING (really interesting new gene) finger, located in the cytosol, and having the unconventional C4HC3 configuration
  • 13 predicted transmembrane domains
  • mono polymer complex
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    basic FUNCTION
  • C4HC3 RING finger-containing ubiquitin ligase, ER degradation substrate itself, promoting its own degradation in a RING finger- and proteasome-dependent manner
  • mediating the degradation of DIO2 (Zavacki 2009)
  • CELLULAR PROCESS protein, ubiquitin dependent proteolysis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    protein ubiquitination
    a component
  • ubiquitin ligase complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Zn2+
  • protein
  • interacting with DIO2 (Zavacki 2009)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS