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FLASH GENE
Symbol MARCH3 contributors: mct/npt - updated : 09-04-2010
HGNC name membrane-associated ring finger (C3HC4) 3
HGNC id 28728
Location 5q23.2      Physical location : 126.203.406 - 126.366.440
Synonym name
  • RING finger protein 173
  • membrane-associated RING-CH protein III
  • Synonym symbol(s) MGC48332, MARCH-III, RNF173, FLJ20096
    EC.number 6.3.2.-
    DNA
    TYPE functioning gene
    STRUCTURE 163.30 kb     5 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 4158 - 253 - Fukuda (2006)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinelarge intestinecolon highly
    Lymphoid/Immunespleen   highly
    Respiratorylung   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short N terminus
  • a RING-CH domain
  • two transmembrane domains
  • HOMOLOGY
    Homologene
    FAMILY
  • MARCH family (membrane-bound E3 ubiquitin ligases)
  • CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    text present in peripheral vesicles partially colocalized with transferrin receptor (Fukuda 2006)
    basic FUNCTION
  • may be involved in the regulation of vesicular trafficking in endosomes (Fukuda 2006)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associated with (syntaxin 6) STX6 and MARCH2
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS