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FLASH GENE
Symbol MAPRE3 contributors: mct - updated : 15-06-2016
HGNC name microtubule-associated protein, RP/EB family, member 3
HGNC id 6892
Location 2p23.3      Physical location : 27.193.524 - 27.250.086
Synonym name
  • APC binding protein
  • dynein light chain rp3
  • end-binding protein 3
    • Synonym symbol(s) EB3, RP3, EBF3, MAE3, EBF3-S
    DNA
    TYPE functioning gene
    STRUCTURE 56.56 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    regionally located close and proximal to ketohexokinase KHK
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1880 - 281 - 2001 11161807
    EBF3L - variant 1
    - splicing 1880 - 268 brain, skeletal muscle 2001 11161807
    including exon 4a
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     parathyroid   highly
    Nervousbraindiencephalonhypothalamus  
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, lens, optic nerve, retina, choroid, RPE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one calponin homology domain( CH)
    • HOMOLOGY
    interspecies homolog to
    intraspecies homolog to MAPRE1
    Homologene
    FAMILY
  • RP/EB family
  • MAPRE family
    • CATEGORY motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text localized to the tip of motile cilia in bronchial epithelial cells and affects the formation of centriole-associated rootlet filaments
    basic FUNCTION
  • involved in microtubule polymerization and spindle function
  • dynein light chain acting as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway
  • involved in SATB1-mediated gene repression of BCL2 and having functions independent of the dynein motor
  • MAPRE1 and MAPRE3, but not MAPRE2, promote persistent microtubule growth by suppressing catastrophes
  • is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase
  • MAPRE1 and MAPRE3 have a role in the axon initial segment (AIS) in addition to their MT plus-end tracking protein behavior in other neuronal compartments
  • MAPRE1 and MAPRE3 coordinate a molecular and functional interplay between ANK3 and the AIS MTs that supports the central role of ANK3 in the maintenance of neuronal polarity
  • MAPRE1 and MAPRE3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that MAPRE1 and MAPRE3 promote ciliogenesis by facilitating such trafficking
  • affect biogenesis of cilia by several centrosome-related mechanisms and support the idea that different MAPRE1-MAPRE3 dimer species have distinct functions within cells
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APC
  • binds to and assembles with the transcription factor SATB1 at nuclear matrix-associated structures (nuclear MAPRE3-SATB1 protein complex is assembled with a DNA element of the matrix attachment region of the BCL2 gene)
  • interaction between drebrin and MAPRE3 is important for the dynamic interaction between F-actin and microtubules that underlies growth-cone formation and neuritogenesis
  • interacting with DLG4 through its SH3 doamain (interaction between DLG4 and MAPRE3 elucidates a function for a novel region of MAPRE3 and provides a new and important mechanism for the regulation of microtubules in determining dendritic morphology)
  • CDH5 outside-in signaling regulates cytosolic Ca2+ homeostasis and MAPRE3 phosphorylation, which are required for assembly of adherens junctions (AJs)
  • TTBK2 with MAPRE1/MAPRE3 phosphorylates KIF2A and antagonizes KIF2A-induced depolymerization at microtubules plus ends for cell migration
    • cell & other
    REGULATION
    Phosphorylated by Aurora-A and Aurora-B, that phosphorylate endogenous MAPRE3 at Ser-176, and the phosphorylation triggers disruption of the MAPRE3-SIAH-1 complex, resulting in EB3 stabilization during mitosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS