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FLASH GENE
Symbol MAPRE3 contributors: mct - updated : 15-06-2012
HGNC name microtubule-associated protein, RP/EB family, member 3
HGNC id 6892
Location 2p23.3      Physical location : 27.193.524 - 27.250.086
Synonym name
  • APC binding protein
  • dynein light chain rp3
  • end-binding protein 3
  • Synonym symbol(s) EB3, RP3, EBF3, MAE3, EBF3-S
    DNA
    TYPE functioning gene
    STRUCTURE 56.56 kb     7 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    OTOF 2p23-p22 otoferlin LOC388936 2 similar to RIKEN cDNA 1700001C02 LOC130106 2p24.1 similar to Calcium and integrin-binding protein 1 (Calmyrin) (DNA-PKcs interacting protein) (Kinase interacting protein) (KIP) (CIB) KCNK3 2p24.1-p23.1 potassium channel, subfamily K, member 3 FLJ20555 CENPA 2p23.1-p22.3 centromere protein A, 17kDa DPYSL5 2p23-p21 dihydropyrimidinase-like 5 MAPRE3 2p23.3-p23.1 microtubule-associated protein, RP/EB family, member 3 FLJ20254 2p23.3 hypothetical protein FLJ20254 FLJ21839 2p23.3 hypothetical protein FLJ21839 EMILIN1 2p23.3-p23.2 elastin microfibril interfacer 1 KHK 2p23.3-p23.2 ketohexokinase (fructokinase) CGREF1 2p23.3 cell growth regulator with EF hand domain 1 ABHD1 2p23.3 abhydrolase domain containing 1 PREB 2p23 prolactin regulatory element binding MGC44505 2p23.3 hypothetical protein MGC44505 LOC391360 2 similar to class II basic helix-loop-helix protein TCF23 SLC5A6 2p23 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 APR-3 2p23.3 solute carrier family 5 (sodium-dependent vitamin transporter), member 6 CAD 2p22-p21 carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase SLC30A3 2p23.3 solute carrier family 30 (zinc transporter), member 3 FLJ40417 2p23.3 gamma cysteine string protein RNF30 2p23.3 ring finger protein 30 UCN 2p23-p21 urocortin MPV17 2p23 MpV17 transgene, murine homolog, glomerulosclerosis GTF3C2 2p23.3 general transcription factor IIIC, polypeptide 2, beta 110kDa
    regionally located close and proximal to ketohexokinase KHK
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 1880 - 281 - 2001 11161807
    EBF3L - variant 1
    - splicing 1880 - 268 brain, skeletal muscle 2001 11161807
    including exon 4a
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     parathyroid   highly
    Nervousbraindiencephalonhypothalamus  
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text eye, lens, optic nerve, retina, choroid, RPE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one calponin homology domain( CH)
  • HOMOLOGY
    interspecies homolog to
    intraspecies homolog to MAPRE1
    Homologene
    FAMILY
  • RP/EB family
  • MAPRE family
  • CATEGORY motor/contractile , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    text localized to the tip of motile cilia in bronchial epithelial cells and affects the formation of centriole-associated rootlet filaments
    basic FUNCTION
  • involved in microtubule polymerization and spindle function
  • dynein light chain acting as a nuclear matrix-associated transcriptional modulator in a dynein-independent pathway
  • involved in SATB1-mediated gene repression of BCL2 and having functions independent of the dynein motor
  • MAPRE1 and MAPRE3, but not MAPRE2, promote persistent microtubule growth by suppressing catastrophes
  • is stable during mitosis, facilitates cell cycle progression at prometaphase, and then is down-regulated during the transition to G(1) phase
  • MAPRE1 and MAPRE3 have a role in the axon initial segment (AIS) in addition to their MT plus-end tracking protein behavior in other neuronal compartments
  • MAPRE1 and MAPRE3 coordinate a molecular and functional interplay between ANK3 and the AIS MTs that supports the central role of ANK3 in the maintenance of neuronal polarity
  • MAPRE1 and MAPRE3 interact with proteins implicated in MT minus-end anchoring or vesicular trafficking to the cilia base, suggesting that MAPRE1 and MAPRE3 promote ciliogenesis by facilitating such trafficking
  • affect biogenesis of cilia by several centrosome-related mechanisms and support the idea that different MAPRE1-MAPRE3 dimer species have distinct functions within cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • APC
  • binds to and assembles with the transcription factor SATB1 at nuclear matrix-associated structures (nuclear MAPRE3-SATB1 protein complex is assembled with a DNA element of the matrix attachment region of the BCL2 gene)
  • interaction between drebrin and MAPRE3 is important for the dynamic interaction between F-actin and microtubules that underlies growth-cone formation and neuritogenesis
  • interacting with DLG4 through its SH3 doamain (interaction between DLG4 and MAPRE3 elucidates a function for a novel region of MAPRE3 and provides a new and important mechanism for the regulation of microtubules in determining dendritic morphology)
  • cell & other
    REGULATION
    Phosphorylated by Aurora-A and Aurora-B, that phosphorylate endogenous MAPRE3 at Ser-176, and the phosphorylation triggers disruption of the MAPRE3-SIAH-1 complex, resulting in EB3 stabilization during mitosis
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS