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FLASH GENE
Symbol MAPKAPK3 contributors: - updated : 15-09-2006
HGNC name mitogen-activated protein kinase-activated protein kinase 3
HGNC id 6888
Location 3p21.2      Physical location : 50.654.600 - 50.686.719
Synonym symbol(s) MAPKAP, 3PK, MAPKAP3
DNA
TYPE functioning gene
STRUCTURE 32.00 kb     11 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
Map pter - D3S3872 - MAPKAPK3 - D3S1648 - cen
Physical map
HYAL2 3p21.3 hyaluronoglucosaminidase 2 PDAP2 3p21.3 PDGFA associated protein 2 RASSF1 3p21.3 Ras association (RalGDS/AF-6) domain family 1 ZMYND10 3p21.3 zinc finger, MYND domain containing 10 NPR2L 101F6 3p21.3 putative tumor suppressor 101F6 PL6 3p21.3 placental protein 6 CACNA2D2 3p21.3 calcium channel, voltage-dependent, alpha 2/delta subunit 2 LOC51161 3p21.3 g20 protein HEMK 3p21.3 HEMK homolog 7kb CISH 3p21.3 cytokine inducible SH2-containing protein MAPKAPK3 3p21.2 mitogen-activated protein kinase-activated protein kinase 3 DOCK3 3p21.31 dedicator of cyto-kinesis 3
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinethyroid   highly
Nervousnervecranial nerve  highly
Skin/Tegumentskin   highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a protein kinase domain
HOMOLOGY
Homologene
FAMILY Ser/Thr protein kinase family
CATEGORY chaperone/stress , signaling
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • modulator of polycomb-mediated repression, which can be activated either by ERK, p38 and JNK
  • functioning as a mitogen-activated protein kinase (MAP kinase)- activated protein kinase
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with TCF3 and with polycomb proteins, such as PCH2 and PCGF4
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in small cell lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS