basic FUNCTION
| involved in many cellular processes including stress and inflammatory responses, nuclear export, gene expression regulation and cell proliferation |
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plays a role in neuroinflammatory and neurodegenerative pathology of relevance to Alzheimer disease |
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cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation |
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MAPKAPK2-mediated LIMK1 phosphorylation/activation plays an essential role in VEGFA-induced actin reorganization, migration, and tubule formation of endothelial cells |
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possible role in the cellular response after neuronal depolarization, in particular in excitotoxicity ( |
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oncogenic and involved in tumor growth and invasion |
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emerges as a regulator of haematopoietic stem cells homeostasis, which could act through chromatin remodelling by the PcG (polycomb group complex) |
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critical role for the MAPKAPK2 pathway in the posttranscriptional regulation of gene expression as part of the DNA damage response in cancer cells |
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important role for MAPK14/MAPKAPK22 signaling in podocyte injury |
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RNA-binding protein that binds to AU-rich elements (AREs) in the 3prime-untranslated region of its target mRNAs and accelerates mRNA degradation |
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in human pulmonary microvascular endothelial cells, regulates TNF-induced expression of ICAM1 and IL8 via tristetraprolin at the mRNA decay level |