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FLASH GENE
Symbol MAPK8IP2 contributors: mct - updated : 23-05-2012
HGNC name mitogen-activated protein kinase 8 interacting protein 2
HGNC id 6883
Location 22q13.33      Physical location : 51.039.130 - 51.049.978
Synonym name
  • islet brain-2
  • JNK MAP kinase scaffold protein 2
  • (JNK)-interacting protein 2
    • Synonym symbol(s) PRKM8IPL, IB2, JIP2
    DNA
    TYPE functioning gene
    STRUCTURE 10.85 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Map cen - D22S272 - D22S423 - XRCC6 - NAGA NAGA - D22S276 D22S282 - D22S1171 - D22S1140 - MAPK8IP1 - D22S1160 - D22S1141 - D22S274 - qter
    Authors Gene Map (98)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 3381 - 824 - 2000 10756100
    10 - 3183 - 797 - 2000 10756100
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas    
    Nervousbrain   highly Homo sapiens
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Endocrineislet cell (alpha,beta...)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal JNK binding domain (IBD)
  • a proline-rich and an acidic region
  • a SH3 domain
  • a phosphotyrosine interacting domain (PID) at the C terminus
    • mono polymer homomer
    HOMOLOGY
    interspecies homolog to murine Jir1 gene
    Homologene
    FAMILY MAP (mitogen activated protein) kinase family
    CATEGORY chaperone/stress , enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    text highly enriched within postsynaptic densities
    basic FUNCTION
  • regulating the JNK signaling pathway in brain and pancreatic beta cells
  • decreasing IL1B induced apoptosis in beta-cells
  • scaffold protein critically required for normal NMDA receptor function
  • scaffold molecule that are implicated in the regulation of the JNK
  • MAPK8IP1 and MAPK8IP2 proteins are required for normal glucose homeostasis, and can influence insulin-stimulated signal transduction mediated by IRS proteins
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    signaling module in which MAPK8IP2 scaffolds a MLK3/MKK/MAPK13 cascade
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • MAP2K8
  • MAP2K7
  • MAPK8
  • weaker APP-binding protein
  • FGF12 and FGF13 aid in recruitment of MAPK14 to MAPK8IP2 and may serve as kinase substrates
  • bind to FGF12, but did not interfere with the anti-apoptotic effect of FGF12
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    is a contributing genetic factor in Chr22qter-associated cognitive disorders
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • disruption of the Mapk8ip2 gene in mice reduces AMPA and enhances NMDA receptor-mediated glutamatergic transmission in cerebellum, changes the morphology of Purkinje cell dendritic arbors, and induces motor and cognitive deficits