| basic FUNCTION
| responding to activation by environmental stress by phosphorylating a number of transcription factor(primarily components of Ap1, C-jun and ATF2) |
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crucial mediator of obesity and insulin resistance |
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required for effector T cell function but not for T cell activation |
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implicated in the immune response that is mediated by the activation and differentiation of CD4 helper T (TH) cells into TH1 and TH2 effector cells  |
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JNK1 signaling pathway plays a key role in T cell receptor-initiated TH cell proliferation, apoptosis, and differentiation |
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implicated in the apoptotic response of cells exposed to stress |
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playing a necessary role for epithelial morphogenesis and essential regulator of signal transduction by the EGF receptor in the epidermis |
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promoting abnormal extracellular matrix metabolism in the tissue (in abdominal aortic aneurysm)through suppression of essential enzymes |
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acting with MAPK8 as sensor and downstream effectors of persistent DNA damage in transcribed genes |
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phosphorylating heat shock factor protein 4 (HSF4) |
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acting as a JUN kinase and MAP kinase (serine/threonine kinase) |
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involved in the activation of pro-apoptotic gene products |
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playong a role in cell mobility |
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involved in the negative regulation of apoptosis |
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involved in UV radiation induced apoptosis |
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playing a key role in T cell proliferation, apoptosis and differentiation |
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its activity is required for protection of liver from hepatic steatosis |
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required for IL-3-mediated cell survival through phosphorylation and inactivation of the proapoptotic Bcl-2 family protein BAD ( |
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JNK pathway is critically involved in diabetes |
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play a role in the developing nervous system and T-cell-mediated immunity |
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necessary for epithelial morphogenesis and is an essential regulator of signal transduction by the EGF receptor in the epidermis |
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may play an important part in maintaining microtubule stability and efficient neurite elongation |
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both MAPK8 and MAPK9, have cytotoxic potential, however MAPK9 is the primary signal transducer |
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implicated in diet-induced obesity |
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role of neuronal and pituitary MAPK8 as a regulator of hypothalamic and peripheral insulin sensitivity as well as somatic growth |
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critical role in pituitary control of thyroid function |
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plays a key role in Ras-induced tumorigenesis |
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has dual roles in the regulation of SIRT1 activity; it induces and then decreases the SIRT1 activity through the phosphorylation-mediated processes |
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MAPK10 mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm |
