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Symbol MAPK3 contributors: mct/shn - updated : 06-10-2020
HGNC name mitogen-activated protein kinase 3
HGNC id 6877
Location 16p11.2      Physical location : 30.125.426 - 30.134.630
Synonym name
  • ERK-1
  • ERT2
  • MAP kinase 1
  • MAP kinase 3
  • MAP kinase isoform p44
  • MAPK 1
  • MAPK 3
  • extracellular signal-regulated kinase 1
  • extracellular signal-related kinase 1
  • Synonym symbol(s) ERK1, PRKM3, P44ERK1, p44mapk, HS44KDAP, HUMKER1A, p44erk1, ERT2, MGC20180
    TYPE functioning gene
    SPECIAL FEATURE head to head
    STRUCTURE 9.20 kb     9 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - D16S3022 - D16S3081 - MAPK3 - D16S753 - cen
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    8 - 2005 40 357 - 1992 1319925
    isoform 2
    8 - 1770 38.1 335 - 1992 1319925
    isoform 3
    9 - 1902 43 379 - 1992 1319925
    isoform 1
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Respiratorylung   highly
    cell lineage
    cell lines head and neck squamous cell carcinoma
    at STAGE
  • N-terminus (AAs 1 to 39)is a domain capable to slow down the nucleocytoplasmic shuttling rate even of a small cargo protein, and able per se to confer a slower shuttling rate to a cargo protein
    interspecies ortholog to Mapk3, Mus musculus
    ortholog to mapk3, Danio rerio
    ortholog to Mapk3, Rattus norvegicus
    ortholog to MAPK3, Pan troglodytes
    intraspecies homolog to MAPK1
  • MAP (mitogen activated protein) kinase family
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • CATEGORY enzyme , receptor membrane serine/threonine kinase
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • a role for a stauro-resistant Bcl2 kinase
  • phosphorylating microtule associated protein 2, myelin basic protein and ELK1
  • promoting entry in the cell cycle
  • activation of MAPK3 is a key regulator of the increased transition to hypertrophic differentiation of the growth plate
  • has a specific role in thymocyte development (
  • a critical regulatory role in the long-term adaptive changes underlying striatum-dependent behavioral plasticity and drug addiction (
  • has a crucial role in cardiac hypertrophy
  • plays a more prominent and dose-dependent role in the pathogenesis of NS-related valve disease than MAPK1
  • playing essential roles in osteoblast differentiation and in supporting osteoclastogenesis
  • plays a key role in the regulation of apoptosis during retinal development (
  • isoform-specific roles of MAPK3 and MAPK1 in the control of arteriogenesis
    signaling signal transduction
    MAPK1/MAPK3 signaling in the neural crest is imperative for normal craniofacial development
    a component
    small molecule
  • p75 nerve growth factor receptors (
  • AP kinase-interacting kinase 1 Mnk1 and Mnk2 (
  • MAP kinase phosphatase 3, MKP3 (
  • PTP-SL and STEP (
  • MEK kinase 1, MEKK1 (
  • Histone deacetylase 4, HDAC4 (
  • MAPK/ERK kinase 1, MEK1 and MAPK/ERK kinase 2, MEK2
  • Mitogen-activated protein (MAP) kinase phosphatase 1? MKP-1/CL100
  • insulin receptor, IR (
  • phosphoprotein enriched in astrocytes 15, PEA15
  • hyaluronan binding protein 1, HABP1 (
  • caveolin-1, CAV1 (
  • MAP kinase Mxi2 (
  • RSK1 (
  • death-associated protein kinase, DAPK (
  • cell division cycle 25 homolog C (S. pombe), CDC25C (
  • death effector domain, DED (
  • class II, major histocompatibility complex transactivator, CIITA (
  • MAPK1/MAPK3 and CEBPB constitute an LH-regulated signaling pathway that controls ovulation- and luteinization-related events
  • FGF21 effects on chondrocyte function are specific and depend on the normal activity of the FGFR1 and MAPK3
  • cell & other
    activated by insulin map kinase
    phosphorylation by TGFB1
    mitogen-activated protein kinase kinase-1 (MAP2K1) and MAP2K2 (commonly referred to as MEK1/2)-dependent phosphorylation in the TEY motif of the activation loop
    dephosphorylated and inactivated by VH1-related, VHR (
    Deleted in colorectal cancer, Dcc
    activated and dephosphorylated by HVH2
    Tissue plasminogen activator, tPA (
    inhibited by increased levels of p67 (
    protein tyrosine phosphatase epsilon, PTP epsilon (
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional somatic mutation      
    Thr188 phosphorylation initiates hypertrophy in cardiomyocytes and is present in failing human hearts
    Variant & Polymorphism
    Candidate gene
    Therapy target
  • p44 MAPK-deficient mice are viable, fertile, and of normal size but p44 MAPK-/- mice thymocyte maturation beyond the CD4+CD8+ stage was reduced by half and proliferation in response to activation with a monoclonal antibody to the T cell receptor in the presence of phorbol myristate acetate was severely reduced (
  • mice lacking ERK1 display a dramatic enhancement of striatum-dependent long-term memory (
  • disrupted Mapk1/mapk3 in mouse granulosa cells provide in vivo evidence that these kinases are necessary for LH-induced oocyte resumption of meiosis, ovulation, and luteinization
  • double knock-out newborn pups for Erk1 and Erk2 survived for not more one day, appeared normal just after parturition, displayed intracerebral hemorrhages with varying location and severity, ventricular zones and corpus callosum did not develop properly and nuclear morphology in some brain regions were markedly aberrant (
  • double knock-out mice deficient for Erk2 in the central nervous system, with ubiquitous homozygous deletion of Erk1 were neonatally lethal (