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FLASH GENE
Symbol MAPK15 contributors: mct - updated : 28-03-2017
HGNC name mitogen-activated protein kinase 15
HGNC id 24667
Location 8q24.3      Physical location : 144.798.506 - 144.804.631
Synonym name
  • extracellular signal-regulated kinase 8
  • extracellular regulated kinase 8 delta
  • Synonym symbol(s) ERK8, ERK7
    EC.number 2.7.11.24
    DNA
    TYPE functioning gene
    STRUCTURE 6.00 kb     12 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1904 59 544 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    Respiratorylung   highly
     respiratory tractlarynx   
    Urinarykidney   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • two SH3-binding motifs in the C-terminal region
  • HOMOLOGY
    intraspecies homolog to ERK7
    Homologene
    FAMILY
  • SER/THR protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • involved in both the initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors such as elk-1
  • involved in protein amino acid phosphorylation
  • CELLULAR PROCESS cell cycle,division,meiosis
    cell cycle, division, mitosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Mg2+
  • protein
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • cell & other
    REGULATION
    activated by tyrosine and threonine phosphorylation
    an Src-dependent signaling pathway
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS