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FLASH GENE

Symbol

MAPK13

contributors: mct - updated : 04-02-2009

HGNC name	mitogen-activated protein kinase 13
HGNC id	6875

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p21.31      Physical location : 36.098.261 - 36.107.841
Synonym name	stress-activated protein kinase 4
	mitogen-activated protein kinase p38 delta
Synonym symbol(s)	SAPK4, PRKM13, p38delta
EC.number	2.7.1.37

DNA

TYPE	like-sequence
STRUCTURE	9.58 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MAPK13 12 - 1888 42 365 - Gutierrez-Sanmartin (2008)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive mouth tongue     highly endocrine brain diencephalon pituitary     Endocrine pancreas           parathyroid       highly Reproductive male system prostate         male system testis       Respiratory lung           respiratory tract larynx     highly Urinary bladder       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial secretory glandular endocrine

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic neutrophil Lymphoid/Immune macrophage Lymphoid/Immune T cell

cell lineage
cell lines	breast cancer
fluid/secretion

at STAGE

physiological period

pregnancy

Text

placenta

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a protein kinase domain
	a nucleotide phosphate binding region
	an ATP binding site

HOMOLOGY

interspecies	ortholog to murine Mapk13
	homolog to Drosophila p38b
	homolog to C.elegans pmk-1

intraspecies	homolog to p38 alpha
	homolog to p38 beta
	homolog to p38 gamma

Homologene

FAMILY	protein kinase superfamily
	CMGC Ser/Thr protein kinase family
	MAP kinase subfamily

CATEGORY

enzyme , regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	having a protein serine/threonine kinase activity
	phosphorylating transcription factor and downstreams targets

CELLULAR PROCESS	cell life, differentiation
	nucleotide, transcription, regulation
	protein, translation regulation

PHYSIOLOGICAL PROCESS

immunity/defense , inflammation

text	microbial antihumoral response

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	ATP
	Mg2+

protein

cell & other

REGULATION

activated by

LBP and CD14

induced by

environmental stress

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS