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FLASH GENE
Symbol MAPK11 contributors: npt/ - updated : 10-04-2007
HGNC name mitogen-activated protein kinase 11
HGNC id 6873
Location 22q13.33      Physical location : 50.702.142 - 50.708.779
Synonym name
  • stress-activated protein kinase B
  • mitogen-activated protein kinase p38-2
  • MAP kinase p38 beta
  • Synonym symbol(s) SAPK2, PRKM11, P38-2, P38BETA2, P38B, SAPK2B, p38Beta
    EC.number 2.7.11.24, 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 6.64 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    ALG12 22q13.3 endothelial cell growth factor 1 (platelet-derived) MGC11256 22p13 hypothetical protein MGC11256 LOC164714 22q13.33 similar to RIKEN cDNA 1700019P01 MLC1 22q13.33 megalencephalic leukoencephalopathy with subcortical cysts 1 MOV10L1 22q13.33 Mov10l1, Moloney leukemia virus 10-like 1, homolog (mouse) PANX2 22q13.33 pannexin 2 PP2447 22q13.33 hypothetical protein PP2447 SELO 22q13.33 selenoprotein O TUBGCP6 22q13.31-q13.33 tubulin, gamma complex associated protein 6 HDAC10 22q13.31 histone deacetylase 10 MAPK12 22q13.33 mitogen-activated protein kinase 12 MAPK11 22q13.33 mitogen-activated protein kinase 11 PLXNB2 22q13.31-q13.33 plexin B2 KIAA0685 22q13.3 plexin B2 SBF1 22q13.33 SET binding factor 1 FLJ21135 ALDRL6 22q13.3 aldehyde reductase (aldose reductase) like 6 BC002942 22q13.33 hypothetical protein BC002942 384D8-2 22q13.33 hypothetical protein 384D8_6 SCO2 22q13.33 SCO cytochrome oxidase deficient homolog 2 (yeast) ECGF1 22q13.3 endothelial cell growth factor 1 (platelet-derived)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 2420 41.23 364 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid   moderately
    Nervousnerve   highly
    Skin/Tegumentskin   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  predominantly
    cell lineage
    cell lines
    fluid/secretion highly in blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a TGY dual phosphorylation site
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Mapk11 (96.7 pc)
    homolog to Drosophila p38b (67.7 pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • phosphorylating ATF2
  • involved in the heat shock sensing mechanism
  • involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
  • involved in the regulation of cyclin D3 levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    text antimicrobial humoral response
    PATHWAY
    metabolism
    signaling signal transduction
    phosphotyrosine mediated pathway
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • Mg2+
  • ATP
  • protein
    cell & other
    REGULATION
    activated by phosphorylation on threonine and tyrosine by MAP2K6
    LBP and CD14 in neutrophils
    induced by proinflammatory cytokines, environmental stress
    inhibited by pyridinyl-imidazole related compounds
    Other promyelocytic leukemia gene negatively regulated the SAPK2/p38 signaling pathway by sequestering p38 from its upstream kinases
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS