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FLASH GENE

Symbol

MAPK11

contributors: npt/ - updated : 10-04-2007

HGNC name	mitogen-activated protein kinase 11
HGNC id	6873

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	22q13.33      Physical location : 50.702.142 - 50.708.779
Synonym name	stress-activated protein kinase B
	mitogen-activated protein kinase p38-2
	MAP kinase p38 beta
Synonym symbol(s)	SAPK2, PRKM11, P38-2, P38BETA2, P38B, SAPK2B, p38Beta
EC.number	2.7.11.24, 2.7.11.1

DNA

TYPE	functioning gene
STRUCTURE	6.64 kb     12 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed MAPK11 12 - 2420 41.23 364 - -

EXPRESSION

Type

widely

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine thyroid       moderately Nervous nerve       highly Skin/Tegument skin       moderately

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective adipose     predominantly

cell lineage
cell lines
fluid/secretion	highly in blood

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a protein kinase domain
	a TGY dual phosphorylation site

conjugated

PhosphoP

HOMOLOGY

interspecies	homolog to murine Mapk11 (96.7 pc)
	homolog to Drosophila p38b (67.7 pc)

Homologene

FAMILY	protein kinase superfamily
	CMGC Ser/Thr protein kinase family
	MAP kinase subfamily

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION

intracellular

basic FUNCTION	phosphorylating ATF2
	involved in the heat shock sensing mechanism
	involved in a signal transduction pathway activated by changes in the osmolarity of the extracellular environment, by cytokines, or by environmental stress
	involved in the regulation of cyclin D3 levels

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

immunity/defense

text	antimicrobial humoral response

PATHWAY

metabolism

signaling

signal transduction

phosphotyrosine mediated pathway

a component

INTERACTION

DNA

RNA

small molecule	metal binding, nucleotide,
	Mg2+
	ATP

protein

cell & other

REGULATION

activated by	phosphorylation on threonine and tyrosine by MAP2K6
	LBP and CD14 in neutrophils

induced by

proinflammatory cytokines, environmental stress

inhibited by

pyridinyl-imidazole related compounds

Other

promyelocytic leukemia gene negatively regulated the SAPK2/p38 signaling pathway by sequestering p38 from its upstream kinases

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS