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FLASH GENE
Symbol MAPK10 contributors: mct/pgu - updated : 20-06-2011
HGNC name mitogen-activated protein kinase 10
HGNC id 6872
Location 4q21.3      Physical location : 86.936.276 - 87.374.283
Synonym name
  • C-Jun kinase 3
  • stress activated protein kinase JNK3
  • stress activated protein kinase beta
  • MAP kinase p49 3F12
  • Synonym symbol(s) JNK3, PRKM10, P493F12, FLJ12099, FLJ33785, JNK3A, p54bSAPK, p493F12
    EC.number 2.7.11.24
    DNA
    TYPE functioning gene
    STRUCTURE 338.17 kb     13 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC152845 4q21.3 similar to product similar to X.laevis finger protein. NKX6-1 4q21.2-q22 NK6 transcription factor related, locus 1 (Drosophila) CDS1 4q21 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1 WDFY3 4q21.23 WD repeat and FYVE domain containing 3 LOC391675 4 LOC391675 DKFZP564B1162 4q22.1 hypothetical protein DKFZp564B1162 MAPK10 4q21-q22 mitogen-activated protein kinase 10 PTPN13 4q21.3 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase) SOAT 4q22.1 sodium-dependent organic anion transporter MGC26744 4q22.1 hypothetical protein MGC26744 LOC260422 4q21.3 actin related protein 2/3 complex subunit 1A pseudogene LOC389210 4 similar to hypothetical protein LOC391676 4 similar to Synaptic glycoprotein SC2 MLLT2 4q21 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2 KLHL8 4q22.1 kelch-like 8 (Drosophila) GAPDL4 4pter-p16.2 glyceraldehyde-3-phosphate dehydrogenase-like 4 SCDR9 4q22.1 short-chain dehydrogenase/reductase 9 DHRS8 4q22.1 dehydrogenase/reductase (SDR family) member 8 NUDT9 4q21.3 nudix (nucleoside diphosphate linked moiety X)-type motif 9 SPARCL1 4q27 SPARC-like 1 (mast9, hevin) DSPP 4q21.3 dentin sialophosphoprotein DMP1 4q21.2-q21.3 dentin matrix acidic phosphoprotein LOC391677 4 similar to chromosome 7 open reading frame 17 protein; 16.7kD protein IBSP 4q21-q25 integrin-binding sialoprotein (bone sialoprotein, bone sialoprotein II) MEPE 4q21.1 matrix, extracellular phosphoglycoprotein with ASARM motif (bone) HSPCP1 4q21-q25 heat shock 90kDa protein 1, beta pseudogene 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 splicing 4186 52 464 - 2011 22047447
  • JNK3- alpha 2, or variant 2
  • both nonvisual arrestins directly bind JNK3alpha2 and its upstream activator MAP2K4, and the affinity of ARR3 for these kinases is higher than that of ARR2
  • enhanced the association between ARR3 with MAP2K4 while reducing ARR3 binding to MAP2K7
  • 13 splicing 3727 47 422 - 2007 17680991
    JNK3- alpha 1 or variant 1
    14 - 4213 - 426 - 2007 17680991
    variant 3, or stress activated protein kinase beta
    9 - 3511 - 277 - 2007 17680991
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Nervousbraindiencephalonhypothalamus highly
     brainforebraincerebral cortex highly
     brainhindbraincerebellum highly
     spinal cord    
    Reproductivemale systemprostate  highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose   
    Muscularstriatumskeletal  
    Nervouscentral   
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • tyrosine kinase catalytic domain
  • HOMOLOGY
    interspecies homolog to murine Mapk10
    Homologene
    FAMILY
  • protein kinase superfamily
  • CMGC Ser/Thr protein kinase family
  • MAP kinase subfamily
  • CATEGORY regulatory , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • mediating apoptosis in central nervous system and role in the development of brain tumors
  • playing an established role in both neuronal differentiation and apoptosis
  • having a pivotal role in regulation of ceramide biosynthesis in cerebral ischemia/reperfusion
  • critical mediator of mutant HTT toxicity, providing a molecular basis for mutant HTT-induced inhibition of fast axonal transport
  • mediates activation of LASS6 in cerebral ischemia/reperfusion
  • critically involved in stress-induced deficit of contextual fear
  • important enzymes in the pathology of diverse neurological disorders
  • mediates potentially its effects mainly at the transcriptional level, while MAPK8 or MAPK9 appear to mediate their pro-apoptotic effect in the cytoplasm
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • components of the two MAPK cascades, MAP3K5-MAP2K4-MAPK10 and RAF1-MAPK1-MAP2K1 interacting with arrestins
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with ARR3 (multiple residues on the non-receptor-binding side of ARR3 are crucial for MAPK10 activation)
  • protects beta-cells from apoptosis and dysfunction mainly through maintenance of a normal IRS2 to AKT2 signaling pathway
  • ARR3 binds MAPK10, MAP2K4, and MAP3K5
  • ARR3 promotes MAPK10 phosphorylation by MAP2K7
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional   deletion    
    in pharmacoresistant epileptic encephalopathy type Lennox-Gastaut
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • Jnk3 null mice showed an increase in pik3cb transcript and protein, together with an increase in PI3K activity and phosphorylation of AKT