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FLASH GENE
Symbol MAP7 contributors: mct - updated : 14-10-2014
HGNC name microtubule-associated protein 7
HGNC id 6869
Location 6q23.3      Physical location : 136.663.872 - 136.871.792
Synonym name
  • ensconsin
  • epithelial microtubule-associated protein of 115 kDa
  • Synonym symbol(s) EMAP115, E.MAP-115
    DNA
    TYPE virus associated
    STRUCTURE 208.73 kb     18 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4326 - 655 - 2001 11719555
    17 - 4497 - 712 - 2001 11719555
    18 - 4608 - 749 - 2001 11719555
    18 - 4248 - 503 - 2001 11719555
    18 - 4375 - 603 - 2001 11719555
    19 - 4515 - 771 - 2001 11719555
    17 - 4401 - 734 - 2001 11719555
    18 - 4512 - 771 - 2001 11719555
    18 - 4245 - 734 - 2001 11719555
    18 - 4536 - 779 - 2001 11719555
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinethyroid    
    Reproductivemale systemprostate   
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal basic domain containing microtubule binding site
  • stretch of amino acids rich in proline and alanine (PAPA region)
  • HOMOLOGY
    interspecies homolog to murine Mtap7
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • playing an essential role in microtubule function required for spermatogenesis (during polarization and differentiation of epithelial cells
  • MAP7 and KIF5B are critical for myonuclear positioning and are not required for fusion and myofibre formation
  • plays a role in relieving autoinhibition of KIF5B (
  • is an essential cofactor for all known functions of KIF5B (
  • promotes microtubule polymerization during mitosis to control spindle length independent of KIF5B
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • may enhance the membrane expression of TRPV4 and possibly link cytoskeletal microfilaments
  • KIF5B requires ensconsin MAP7 for its primary function of organelle transport
  • cooperates with its binding partner KIF5B during interphase to trigger centrosome separation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS