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FLASH GENE
Symbol MAP4K3 contributors: mct/npt - updated : 29-10-2009
HGNC name mitogen-activated protein kinase kinase kinase kinase 3
HGNC id 6865
Location 2p22.2      Physical location : 39.476.422 - 39.664.219
Synonym name
  • RAB8 interacting protein like 1
  • germinal center kinase-like kinase
  • MAPK/ERK kinase kinase kinase 3
  • Synonym symbol(s) GLK, MAPKKKK3, RAB8IPL1
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 187.80 kb     34 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    FEZ2 2p21 fasciculation and elongation protein zeta 2 (zygin II) VIT 2p22-p21 vitrin STRN 2p22-p21 striatin, calmodulin binding protein KIAA1414 2p22.3 KIAA1414 protein FLJ38348 2p22.3 hypothetical protein FLJ38348 PRKR 2p22-p21 protein kinase, interferon-inducible double stranded RNA dependent LOC391365 2 similar to sulfotransferase CBF2 2p23.1 similar to sulfotransferase PRO1853 2p22.3 hypothetical protein PRO1853 PRKCN 2p21 protein kinase C, nu QPCT 2p22.3 glutaminyl-peptide cyclotransferase (glutaminyl cyclase) CDC42EP3 2p21 CDC42 effector protein (Rho GTPase binding) 3 LOC344382 2p22.3 similar to UNR-interacting protein (WD-40 repeat protein PT-WD) (MAP activator with WD repeats) FLJ32954 2p22.3 hypothetical protein FLJ32954 CYP1B1 2p21 cytochrome P450, family 1, subfamily B, polypeptide 1 MGC34824 2p22.3 hypothetical protein MGC34824 LOC391366 2 similar to ribosomal protein L7 LOC391367 2 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) ARL6IP2 2p22.3 similar to Glyceraldehyde 3-phosphate dehydrogenase, liver (GAPDH) LOC388940 2 LOC388940 LOC220717 2p22.3 similar to BLOCK 23 LOC92906 2p22.3 hypothetical protein BC008217 LOC130589 SFRS7 2p22-p21 splicing factor, arginine/serine-rich 7, 35kDa GEMIN6 2p22.3 gem (nuclear organelle) associated protein 6 DHX57 2p22.3 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 ASSP2 6q14.3-q15 argininosuccinate synthetase pseudogene 2 LOC387626 2 hypothetical gene supported by NM_144995 MOPT  protein containing single MORN motif in testis SOS1 2p22-p21 son of sevenless homolog 1 (Drosophila) LOC344387 2p22.3 similar to cyclin-dependent kinase-like 1 (CDC2-related kinase) MAP4K3 2p22.2 mitogen-activated protein kinase kinase kinase kinase 3 MGC33926 2p22.2 hypothetical protein MGC33926 C2orf8 2p22-p21 chromosome 2 open reading frame 8 LOC391368 2 similar to Zinc finger protein 19 (Zinc finger protein KOX12) SLC8A1 2p23-p22 solute carrier family 8 (sodium/calcium exchanger), member 1 LOC388941 2 similar to hypothetical protein (L1H 3 region) - human LOC391369 2 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) LOC284397 2p22.1 similar to FKSG60 LOC391370 2 similar to ribosomal protein S12 LOC388942 2 hypothetical gene supported by AK126414
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    34 - 4141 101.3 894 - -
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    Nervousbrain    
    Respiratorylung    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelialsecretoryglandularendocrine 
    Epithelialsecretoryglandularexocrine 
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N terminal catalytic domain (tyrosine kinase)
  • two PEST motifs
  • three proline-rich region
  • C-terminal PEST domain that might play a role in the modulation of MAP4K3 stability through regulation by the ubiquitin-proteasome system (Lam 2009)
  • HOMOLOGY
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • serine/threonine protein kinase activity
  • activating the C-JUN-N-terminal kinase (JNK) signaling pathway
  • required for maximal RPS6/EIF4EBP1 phosphorylation and regulates cell growth (Findlay 2007)
  • can act as a general mediator of DNA damage-induced cell death (Lam 2009)
  • pro-apoptotic kinase that induces mitochondria-dependent apoptosis via BAX activation (Lam 2009)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP
  • protein
  • contributes to the activation of both the JNK and mTOR signaling pathways (Lam 2009)
  • modulates the activity of the BH3 proteins BBC3, BAD, and BCL2L11 at the posttranscriptional level (Lam 2009)
  • cell & other
    REGULATION
    activated by phosphorylation
    exposure to UV radiation or to tumor necrosis factor-alpha
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional        
    resulted in significant resistance to DNA damage-induced cell death (Lam 2009)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS