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FLASH GENE
Symbol MAP4K1 contributors: mct/npt - updated : 27-05-2019
HGNC name mitogen-activated protein kinase kinase kinase kinase 1
HGNC id 6863
Location 19q13.2      Physical location : 39.078.280 - 39.108.643
Synonym name
  • hematopoietic progenitor kinase 1
  • MEK kinase kinase 1
  • MAPK/ERK kinase kinase kinase 1
  • Synonym symbol(s) HPK1
    EC.number 2.7.11.1
    DNA
    TYPE functioning gene
    STRUCTURE 30.36 kb     31 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map cen - D19S425 - D19S208 - D19S224 - SCN1B - D19S228 - D19S421 - D19S223 - MAP4K1 - D19S211 - D19S219 - D19S412 - D19S606 - D19S907 - KLK1 - RPS9 - D19S571 - D19S927 - D19S418 - qter
    Authors Gene Map (98)
    Physical map
    DPF1 19q13.13 D4, zinc and double PHD fingers family 1 PPP1R14A 19q13.13-q13.2 protein phosphatase 1, regulatory (inhibitor) subunit 14A SPINT2 19q13.1 serine protease inhibitor, Kunitz type, 2 IMUP 19q13.13 serine protease inhibitor, Kunitz type, 2 LOC90522 19q13.13 similar to putative transmembrane protein; homolog of yeast Golgi membrane protein Yif1p (Yip1p-interacting factor) KCNK6 19q13.1 potassium channel, subfamily K, member 6 DKFZP434A1022 PSMD8 19q13.13 proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 GGN 19q13.13 gametogenetin LOC388538 19 similar to SPRED-3 LOC147965 19q13.2 hypothetical protein LOC147965 RASGRP4 19q13.1 RAS guanyl releasing protein 4 RYR1 19q13.1 ryanodine receptor 1 (skeletal) MAP4K1 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 eIF3k 19q13.2 mitogen-activated protein kinase kinase kinase kinase 1 ACTN4 19q13 actinin, alpha 4 CAPN12 19q13.2 calpain 12 LGALS7 19q13.2 lectin, galactoside-binding, soluble, 7 (galectin 7) LGALS4 19q13.2 lectin, galactoside-binding, soluble, 4 (galectin 4) ECH1 19q13.1 enoyl Coenzyme A hydratase 1, peroxisomal HNRPL 19q13.2 heterogeneous nuclear ribonucleoprotein L FLJ45909 19q13.2 FLJ45909 protein SIRT2 19q13 sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) NFKBIB 19q13.1 nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta LOC388539 19 LOC388539 SARS2 19q13.2 seryl-tRNA synthetase 2
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    31 - 2681 - 821 - -
    32 - 2779 91.3 833 - -
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connectivebone   
    cell lineage predominantly, in hematopoietic cells
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal
    Text liver
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • an N-terminal kinase domain, HPK1-N, comprising the kinase domain, confering progenitor cell survival independent of the growth factor IL3 (Arnold 2007)
  • a C-terminal citron homology (CNH) domain, HPK1-C, suppresses NF-kappaB and sensitizes toward activation-induced cell death by a yet undefined cell death pathway (Brenner 2007)
  • HOMOLOGY
    interspecies homolog to murine Map4k1
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • STE20 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • activation of JUN kinase in the MEKK/JNK/SAPK signaling pathway
  • protein phosphorylation (serine/threonine kinase) activity
  • stress response
  • essential for NF-kappaB activation in T cells (Brenner 2007)
  • kinase specific for CARD11 and MAP4K1-mediated phosphorylation of CARD11 as an additional regulatory mechanism tuning the NF-KB response upon TCR stimulation (Brenner 2009)
  • regulator of TCR-mediated NF-KB activation and that NF-KB activation via MAP4K1 is dependent on CARD11 (Brenner 2009)
  • may function as a novel tumor suppressor and its loss plays a critical role in pancreatic cancer (Wang 2009)
  • regulates stress responses, proliferation, and apoptosis in hematopoietic cells (Wang 2009)
  • regulates stress responses, proliferation, and apoptosis in hematopoietic cells
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with CARD11 in a TCR stimulation-dependent manner and phosphorylates the linker region of CARD11 (Brenner 2009)
  • CUL7/FBXW8 ubiquitin ligase-mediated MAP4K1 degradation revealed a direct link and novel role of CUL7/FBXW8 ubiquitin ligase in the MAPK pathway, which plays a critical role in cell proliferation and differentiation
  • PDIA6 interacted with MAP4K1 and inhibited its phosphorylation, ultimately inhibiting the JNK/JUN signaling pathway
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS