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FLASH GENE
Symbol MAP4 contributors: shn - updated : 30-08-2017
HGNC name microtubule-associated protein 4
HGNC id 6862
Location 3p21.31      Physical location : 47.892.179 - 48.130.769
Synonym symbol(s) DKFZp779A1753, MGC8617, MTAP4
DNA
TYPE functioning gene
STRUCTURE 238.59 kb     19 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status confirmed
Map pter - D3S3582 - D3S1767 - MAP4 - D3S3560 - D3S2384 - cen
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
19 splicing 6337 - 1152 - -
19 splicing 6046 - 1135 - -
4 splicing 3224 - 99 - -
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon moderately
Nervousbrain   highly
 nerve   highly
Visualeye   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Connectivebone  moderately
Muscularstriatumskeletal highly
cell lineage
cell lines
fluid/secretion lymph
at STAGE
physiological period
Text embryonic tissue
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • tandem related repeats of approximatly 14 amino acods, a region with clusters of proline and serine
  • a C terminal region with three imperfect 18 amino acids repeats homolog to the MT binding domain of MAP2 and MAPT
  • four TAU/MAP repeats
  • HOMOLOGY
    interspecies ortholog to Map4, Rattus norvegicus
    ortholog to Mtap4, Mus musculus
    Homologene
    FAMILY MAP (mitogen activated protein) kinase family
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • promoting microtubule assembly, and counteracting destabilization of interphase microtubule catastrophe promotion
  • involved in the regulation of microtubule stability
  • involved in microtubule network stability and microtubule network density by its phosphorylation
  • CLASP1 is required to correctly capture astral microtubules, whereas MAP4 prevents engagement of excess dynein motors, thereby protecting the system from force imbalance
  • MAP4 and the microtubule rescue factor CLASP1 are essential for maintaining spindle position and the correct cell-division axis in human cells
  • unexpected role of TRAF3IP1 as a negative regulator of microtubule stability via MAP4 (microtubule-associated protein 4)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • Cyclin B
  • physically interacts with dynein-dynactin and inhibits dynein-mediated microtubule sliding
  • MAP4, which is a binding partner of SEPT2, controls the accessibility of septins to microtubules
  • cell & other
    REGULATION
    Other phosphorylated by protein kinase p110mark
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    of exon 9 of MALT1 and exon 9 of MAP4 in diffuse large B-cell lymphoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS