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FLASH GENE
Symbol MAP3K9 contributors: mct - updated : 14-09-2013
HGNC name mitogen-activated protein kinase kinase kinase 9
HGNC id 6861
Location 14q24.2      Physical location : 71.194.855 - 71.275.888
Synonym name mixed lineage kinase 1, dual (tyr and ser/thr specificity)
Synonym symbol(s) PRKE1, MLK1, MEKK9
EC.number 2.7.11.25
DNA
TYPE functioning gene
STRUCTURE 81.04 kb     13 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
13 - 5602 - 1118 - 2008 18032450
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrinepancreas   highly
Lymphoid/Immunespleen   highly
Nervousbrain   highly
Visualeye   highly
cell lineage
cell lines epithelial tumor cell lines of colonic, breast and oesophageal origin
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • N terminal catalytic domain with eleven kinase motifs, hybrid between those of serine/threonine and tyrosine protein kinases
  • a double leucine zipper domain
  • a SH3 domain
  • a basic sequence in the C terminus
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans C08f8.6
    Homologene
    FAMILY
  • MAP (mitogen activated protein) kinase family
  • CATEGORY enzyme , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • activating the jun N-terminal pathway
  • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
  • magnesium
  • protein
    cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS