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FLASH GENE
Symbol MAP3K6 contributors: SGE/npt - updated : 19-09-2019
HGNC name mitogen-activated protein kinase kinase kinase 6
HGNC id 6858
Location 1p36.11      Physical location : 27.681.669 - 27.693.337
Synonym name apoptosis signal-regulating kinase 2
Synonym symbol(s) MAPKKK6, ASK2, MGC20114, MGC125653
EC.number 2.7.11.25
DNA
TYPE functioning gene
STRUCTURE 11.67 kb     29 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Physical map
LIN28 1p35.3 lin-28 homolog (C. elegans) DHDDS 1p35.3 dehydrodolichyl diphosphate synthase HMGN2 1p36.1 high-mobility group nucleosomal binding domain 2 RPS6KA1 1p36-p35 ribosomal protein S6 kinase, 90kDa, polypeptide 1 SMARCF1 1p36.1-p35 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily f, member 1 FLJ20477 1p35.3 hypothetical protein FLJ20477 ZDHHC18 1p35.3 zinc finger, DHHC domain containing 18 SFN 1p35.3 stratifin FLJ10349 1p35.3 hypothetical protein FLJ10349 FLJ12455 1p35.3-p35.1 hypothetical protein FLJ12455 NR0B2 1p36.1 nuclear receptor subfamily 0, group B, member 2 NUDC 1p35-p34 nuclear distribution gene C homolog (A. nidulans) FLJ34633 1p35.3 hypothetical protein FLJ34633 LOC391022 1 similar to DC2 protein LOC388610 1 LOC388610 MGC16491 1p35.3 hypothetical protein MGC16491 SLC9A1 1p35 solute carrier family 9 (sodium/hydrogen exchanger), isoform 1 (antiporter, Na+/H+, amiloride sensitive) LOC391023 1 similar to ribosomal protein L18a; 60S ribosomal protein L18a LOC284609 1p35.3 similar to hypothetical protein FLJ20420 LOC148356 1p35.3 similar to nucleophosmin 1; nucleolar phosphoprotein B23; numatrin; nucleophosmin/nucleoplasmin family, member 1 WDTC1 1p35.3 WD and tetratricopeptide repeats 1 DKFZP564D0478 1p35.3 hypothetical protein DKFZp564D0478 JFC1 1p35.3 hypothetical protein DKFZp564D0478 MAP3K6 1p35.2 mitogen-activated protein kinase kinase kinase 6 FCN3 1p36-p32 ficolin (collagen/fibrinogen domain containing) 3 (Hakata antigen) LOC388611 1 similar to EAPG6122 GPR3 1p35.1-p34.3 G protein-coupled receptor 3 WASF2 1p36.11-p34.3 WAS protein family, member 2 DJ159A19.3 1p36.13 hypothetical protein DJ159A19.3 LOC388612 1 LOC388612 FGR 1p35 Gardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog G1P3 1p35 interferon, alpha-inducible protein (clone IFI-6-16) LOC339409 1p35.3 similar to Procollagen (type III) N-endopeptidase MGC34648 1p35.3 hypothetical protein MGC34648 STX12 1p35-p34.1 syntaxin 12 PPP1R8 1p35 protein phosphatase 1, regulatory (inhibitor) subunit 8 C1orf38 1p35.2 chromosome 1 open reading frame 38 RPA2 1p35 replication protein A2, 32kDa ASML3B 1p35.2 acid sphingomyelinase-like phosphodiesterase FLJ10307 1p35.2 hypothetical protein FLJ10307 EYA3 1p36 eyes absent homolog 3 (Drosophila) LOC388613 1 similar to Microsomal signal peptidase 25 kDa subunit (SPase 25 kDa subunit) (SPC25) LOC391024 1 similar to RIKEN cDNA 2610313E07 PTAFR 1p35.1-p34.3 platelet-activating factor receptor
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 4333 142 1288 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 stomach   highly
Respiratorylung   highly
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain with eleven kinase motifs
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Map3k6 (87.8pc)
    Homologene
    FAMILY
  • MAP (mitogen-activated protein) kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine protein kinase activity
  • regulating stress-induced caspase-3 and PARP cleavage in a dose-dependent manner by heteromeric complex formation with MAP3K5
  • in cooperation with MAP3K5 functioned as a tumour suppressor by exerting proapoptotic activity in epithelial cells, which was consistent with the reduction in MAP3K6 expression in cancer cells and tissues (Iriyama 2009)
  • with MAP3K5 are critically involved in tumorigenesis by differentially regulating apoptosis and inflammation (Iriyama 2009)
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    JNK cascade
    a component
  • heterodimerizing with MAP3K5
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ion Mg2+ binding
  • ATP binding
  • protein
  • interacting with MAP3K5
  • MAP3K5, MAP3K6 was required for NLRP3 up-regulation after lipopolysaccharide treatment in primary bone marrow-derived macrophages and lung fibroblasts as well as during infection with Burkholderia thailandensis and influenza virus
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS