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FLASH GENE
Symbol MAP3K6 contributors: SGE/npt - updated : 19-09-2019
HGNC name mitogen-activated protein kinase kinase kinase 6
HGNC id 6858
Location 1p36.11      Physical location : 27.681.669 - 27.693.337
Synonym name apoptosis signal-regulating kinase 2
Synonym symbol(s) MAPKKK6, ASK2, MGC20114, MGC125653
EC.number 2.7.11.25
DNA
TYPE functioning gene
STRUCTURE 11.67 kb     29 Exon(s)
Genomic sequence alignment details
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
29 - 4333 142 1288 - -
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestine   highly
 stomach   highly
Respiratorylung   highly
Skin/Tegumentskin   highly
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a catalytic domain with eleven kinase motifs
  • conjugated PhosphoP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    interspecies homolog to murine Map3k6 (87.8pc)
    Homologene
    FAMILY
  • MAP (mitogen-activated protein) kinase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    basic FUNCTION
  • serine/threonine protein kinase activity
  • regulating stress-induced caspase-3 and PARP cleavage in a dose-dependent manner by heteromeric complex formation with MAP3K5
  • in cooperation with MAP3K5 functioned as a tumour suppressor by exerting proapoptotic activity in epithelial cells, which was consistent with the reduction in MAP3K6 expression in cancer cells and tissues (Iriyama 2009)
  • with MAP3K5 are critically involved in tumorigenesis by differentially regulating apoptosis and inflammation (Iriyama 2009)
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    JNK cascade
    a component
  • heterodimerizing with MAP3K5
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ion Mg2+ binding
  • ATP binding
  • protein
  • interacting with MAP3K5
  • MAP3K5, MAP3K6 was required for NLRP3 up-regulation after lipopolysaccharide treatment in primary bone marrow-derived macrophages and lung fibroblasts as well as during infection with Burkholderia thailandensis and influenza virus
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS