protein
| TRAF family |
|
PPP5C |
|
ARBB2 |
|
DAXX |
|
DUSP19 |
|
interacting with AKT2 and DAB2IP |
|
binding to PKR |
|
forming a complex with IGF1R |
|
direct E2F1 target gene |
|
interacts with PRDX1 via its thioredoxin-binding domain (interaction highly inducible by H2O2)(Kim 2008) |
|
interacting with PGAM5 (associates with the MAP kinase kinase kinase MAP3K5 and acts as a specific protein Ser/Thr phosphatase that activates MAP3K5 by dephosphorylation of inhibitory sites) |
|
association between MAP3K5 and STRAP is mediated through the C-terminal domain of MAP3K5 and the fourth and sixth WD40 repeats of STRAP |
|
stabilizes SMN protein by inhibiting SMN poly-ubiquitination, and the kinase activity of MAP3K5 is less important than its ability to bind to SMN |
|
ZNF622 physically interact with MAP3K5 |
|
NOTCH1-intracellular domain may act as a negative regulator in MAP3K5 signaling cascades |
|
ARR3 binds MAPK10, MAP2K4, and MAP3K5 |
|
MAP3K5 a representative stress kinase, interacts with both GAPDH and SIAH1 and is likely able to phosphorylate Siah1 at specific amino acid residues |
|
PPIA negatively regulates MAP3K5 functions by its physical interaction with MAP3K5 |
|
YWHAE interacts with the kinase domain of MAP3K5 in close proximity to its active site, thus indicating this interaction might block its accessibility and/or affect its conformation |
|
TXN dissociates in response to oxidative stress allowing the MAP3K5 activation |
|
the catalytic site of TXN interacts with MAP3K5-TXN-binding domain(TBD) region containing cysteine C200 and the oxidative stress induces intramolecular disulfide bond formation within MAP3K5-TBD |
|
LRRK2 played an important role in neuronal cell death by directly phosphorylating and activating apoptosis signal-regulating kinase 1 (MAP3K5) |
|
TRIM48 orchestrates the regulation of oxidative stress-induced MAP3K5 activation |
|
TRIM48 facilitates MAP3K5 activation by promoting K48-linked polyubiquitination and degradation of PRMT1 |
|
TNFAIP3 is a key endogenous suppressor of MAP3K5 activation, and TNFAIP3 directly interacts with and deubiquitinates MAP3K5 in hepatocytes |
|
MAP3K5, MAP3K6 was required for NLRP3 up-regulation after lipopolysaccharide treatment in primary bone marrow-derived macrophages and lung fibroblasts as well as during infection with Burkholderia thailandensis and influenza virus |
|
BTRC and FBXW11 is capable of suppressing oxidative stress-induced CASP3-dependent apoptosis through suppression of MAP3K5, assisting in the organism's ability to maintain homeostasis in an unstable environment |