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FLASH GENE
Symbol MAP3K2 contributors: mct - updated : 25-03-2015
HGNC name mitogen-activated protein kinase kinase kinase 2
HGNC id 6854
Location 2q14.3      Physical location : 128.062.138 - 128.100.770
Synonym name
  • MAP/ERK kinase kinase 2
  • MEK kinase 2
  • Synonym symbol(s) MEKK2, MEKK2B
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 38.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    Physical map
    LOC150554 2q21.1 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta pseudogene GYPC 2q14-q21 glycophorin C (Gerbich blood group) LOC339760 2q21.1 hypothetical LOC339760 BIN1 2q14 bridging integrator 1 LOC389029 2 LOC389029 LOC339761 2q21.1 similar to 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial precursor (Calcidiol 1-monooxygenase) (25-OHD-1 alpha-hydroxylase) (25-hydroxyvitamin D(3) 1-alpha-hydroxylase) (VD3 1A hydroxylase) (P450C1 alpha) (P450VD1-alpha) ERCC3 2q21 excision repair cross-complementing rodent repair deficiency, complementation group 3 (xeroderma pigmentosum group B complementing) MAP3K2 2q14.3 mitogen-activated protein kinase kinase kinase 2 LOC389030 2 LOC389030 PROC 2q13-q14 protein C (inactivator of coagulation factors Va and VIIIa) FLJ10006 2q21.1 hypothetical protein FLJ10006 LOC389031 2 similar to myosin-VIIb MYO7B 2q21.1 myosin VIIB LIMS2 2q14.2 LIM and senescent cell antigen-like domains 2 GPR17 2q21 G protein-coupled receptor 17 MGC5391 2q21.1 hypothetical protein MGC5391 FLJ11294 2q21.1 hypothetical protein FLJ11294 POLR2D 2q21 polymerase (RNA) II (DNA directed) polypeptide D MGC4268 2q21 hypothetical protein MGC4268 SAP130 2q21.1 mSin3A-associated protein 130 UGCGL1 2q14.2 UDP-glucose ceramide glucosyltransferase-like 1 HS6ST1 2q21 heparan sulfate 6-O-sulfotransferase 1 LOC391432 2 similar to hypothetical protein LOC389032 2 LOC389032 LOC391433 2 similar to peptidyl-Pro cis trans isomerase
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4941 - 619 - Wissing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     parathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map3k2
    homolog to C.elegans F27c1.6
    Homologene
    FAMILY MAP (mitogen-activated protein) kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION plays a role in NF-kappa B signaling pathway, activate protein kinase C-related kinase 2, and may be involved in a regulated signaling process
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAPKAP1 (regulates MAP3K2 dimerization and activation by forming a complex with inactive and nonphosphorylated MAP3K2)
  • potent activator of the JNK pathway in fibroblast-like synoviocytes
  • MAP3K2 and MAP3K3 negatively regulated transforming growth factor-beta (TGFB1)-mediated Th cell differentiation
  • cell & other
    REGULATION
    activated by phosphorylation
    the TLR and cellular stress pathways
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS