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FLASH GENE
Symbol MAP3K2 contributors: mct - updated : 25-03-2016
HGNC name mitogen-activated protein kinase kinase kinase 2
HGNC id 6854
Location 2q14.3      Physical location : 128.062.138 - 128.100.770
Synonym name
  • MAP/ERK kinase kinase 2
  • MEK kinase 2
  • Synonym symbol(s) MEKK2, MEKK2B
    EC.number 2.7.1.37
    DNA
    TYPE functioning gene
    STRUCTURE 38.00 kb     16 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned   linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4941 - 619 - Wissing (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Endocrinepancreas   highly
     parathyroid   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map3k2
    homolog to C.elegans F27c1.6
    Homologene
    FAMILY MAP (mitogen-activated protein) kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION plays a role in NF-kappa B signaling pathway, activate protein kinase C-related kinase 2, and may be involved in a regulated signaling process
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with MAPKAP1 (regulates MAP3K2 dimerization and activation by forming a complex with inactive and nonphosphorylated MAP3K2)
  • potent activator of the JNK pathway in fibroblast-like synoviocytes
  • MAP3K2 and MAP3K3 negatively regulated transforming growth factor-beta (TGFB1)-mediated Th cell differentiation
  • methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas
  • MAP3K2 serves as a robust substrate of SMYD3 because of the presence of a phenylalanine residue at the -2 position
  • cell & other
    REGULATION
    activated by phosphorylation
    the TLR and cellular stress pathways
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS