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FLASH GENE
Symbol MAP3K14 contributors: mct - updated : 02-01-2017
HGNC name mitogen-activated protein kinase kinase kinase 14
HGNC id 6853
Location 17q21.31      Physical location : 43.340.487 - 43.394.414
Synonym name
  • serine/threonine protein kinase
  • NF-kappa beta-inducing kinase
  • Synonym symbol(s) NIKPK, MS, NIK, MSNIK, FTDCR1B, HS, HSNIK
    EC.number 2.7.11.25
    DNA
    TYPE functioning gene
    STRUCTURE 53.93 kb     17 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map see MAPT
    Physical map
    KIAA0553 17q21.31 KIAA0553 protein FZD2 17q21.1 frizzled homolog 2 (Drosophila) FLJ35848 17q21.31 hypothetical protein FLJ35848 FLJ31795 17q21.31 hypothetical protein FLJ31795 DRF1 17q21.31 Dbf4-related factor 1 ADAM11 17q21.3 a disintegrin and metalloproteinase domain 11 GJA7 17q21.31 gap junction protein, alpha 7, 45kDa (connexin 45) CLST11240 17q21.31 CLST 11240 protein U5-116KD 17q21.31 U5 snRNP-specific protein, 116 kD LOC388389 17 similar to RIKEN cDNA 4933439F11 GFAP 17q21.1 glial fibrillary acidic protein LOC146909 17q21.31 hypothetical protein LOC146909 CRF 17q21 C1q-related factor FLJ22955 17q21.31 hypothetical protein FLJ22955 NMT1 17q21.32 N-myristoyltransferase 1 PLCD3 17q21 phospholipase C, delta 3 ACBD4 17q21.31 acyl-Coenzyme A binding domain containing 4 HIS1 17q21.1 acyl-Coenzyme A binding domain containing 4 FLJ32384 17q21.31 hypothetical protein MGC39389 FMNL1 17q21 formin-like 1 FLJ25414 17q21.31 hypothetical protein FLJ25414 MAP3K14 17q21 mitogen-activated protein kinase kinase kinase 14 LOC388390 17 LOC388390 LOC201176 17q21.31 similar to Rho GTPase activating protein 12 LOC201175 17q21.31 hypothetical protein LOC201175 KIAA0356 17q21.1-q23.2 hypothetical protein LOC201175 FLJ10120 17q21.31 hypothetical protein FLJ10120 LOC388391 17 similar to KIAA0563 protein LOC339193 17q21.31 similar to dead end homolog 1; dead end protein FLJ25168 17q21.31 hypothetical protein FLJ25168 CRHR1 17q12-q22 corticotropin releasing hormone receptor 1 IMP5 17q21.31 intramembrane protease 5 MAPT 17q21.11 microtubule-associated protein tau DKFZP727C091
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    16 - 4468 - 947 - 2003 12853971
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestiveintestinesmall intestine  highly
    Lymphoid/Immunespleen   highly
     thymus   highly
    Reproductivefemale systemuteruscervix highly
     male systemprostate  moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoietic    
    Lymphoid    
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map3k14 (85.0pc)
    homolog to rattus Map3k14 (85.7pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus,nucleolus
    text nuclear MAP3K14 is capable of activating NF-kappaB
    basic FUNCTION
  • participating in NF-kappa-B-inducing signalling cascade common to TNF/NGF receptors family and IL1R
  • involved in the constitutive activation of the alternative pathways and controlling cell proliferation in pancreatic cancer cells
  • selective role in signaling by the LTBR
  • component of the EGF/heregulin receptor signaling complexes
  • SMG1 and MAP3K14 function as critical repressors of Smac mimetic compounds-mediated apoptosis by potentially converging on the regulation of CFLAR metabolism
  • role of TRAF3 and MAP3K14 in T cell malignancies, indicating that TRAF3 differentially governs the growth of B and T cell cancers
  • non-redundant role for MAP3K14 in human immune responses, demonstrating that loss-of-function mutations in MAP3K14 can cause multiple aberrations of lymphoid immunity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • TRAF2/MAP3K14/NFKB2 pathway regulates pancreatic ductal adenocarcinoma (PDAC) cell tumorigenicity
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding TRAF2, TRAF5, TRAF6, IKKA (IKBKA) and stimulating NF-kappa-B activity
  • interacting with PEBP1
  • interacting with RCAN1 in brain and phosphorylating it, increasing its stability and blocking its proteasomal degradation
  • cooperates with MAP3K8 to trigger NF-Kappa B p65 phosphorylation
  • its expression is negatively regulated by the full-length isoform of TRAF3 as formation of a MAP3K14-TRAF3-TRAF2 complex targets MAP3K14 for degradation
  • cell & other
    REGULATION
    activated by phosphorylation and IL1
    repressed by TNAP
    Other HIV Tat can substantially enhance the capacity of MAP3K14 to accelerate degradation of IKappaB
    redox regulation of MAP3K14 by H2O2 is mechanistically important in IL-1 beta induction of NF-Kappa activation
    critical target of reactive oxygen species in NF-kappaB pathways in oral squamous carcinoma cells
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
    significantly expressed in pancreatic cancer cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    TRAF2/MAP3K14/NFKB2 pathway could be a valuable target for therapy of this cancer
    ANIMAL & CELL MODELS