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FLASH GENE
Symbol MAP3K13 contributors: - updated : 15-11-2006
HGNC name mitogen-activated protein kinase kinase kinase 13
HGNC id 6852
Location 3q27      Physical location : 185.080.969 - 185.200.624
Synonym name leucine zipper bearing kinase
Synonym symbol(s) LZK, MGC133196
EC.number 2.7.1.37
DNA
TYPE functioning gene
STRUCTURE 119.00 kb     14 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status provisional
Map cen - D3S1553 - BCHE BCHE - D3S1258 - D3S1614 - D3S1282 - D3S1564 - SLC2A2 SLC2A2 - D3S1565 - D3S1617 - MAP3K13 - AHSG - ST6GAL1 - D3S1580 - qter
Authors GeneMap (98),LDB (99)
Physical map
ECE2 3q27q28 endothelin converting enzyme 2 PSMD2 3q27.3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 EIF4G1 3q27-qter eukaryotic translation initiation factor 4 gamma, 1 MGC21688 3q27.3 hypothetical protein MGC21688 CLCN2 3q27-q28 chloride channel 2 POLR2H 3q28 polymerase (RNA) II (DNA directed) polypeptide H THPO 3q27-q28 thrombopoietin (myeloproliferative leukemia virus oncogene ligand, megakaryocyte growth and development factor) CHRD 3q27 chordin LOC285248 3q27.3 hypothetical LOC285248 LOC391600 3 similar to RIKEN cDNA 2310042E22 EPHB3 3q21-qter EphB3 MAGEF1 3q13 EphB3 LOC389182 3 LOC389182 KIAA0804 3q28 LOC389182 LOC285382 3q28 hypothetical gene supported by AK091454 LOC339926 3q28 hypothetical LOC339926 LOC391601 3 similar to alpha-1 platein precursor EHHADH 3q26.3-q28 enoyl-Coenzyme A, hydratase/3-hydroxyacyl Coenzyme A dehydrogenase LOC347673 3q26.3-q28 eukaryotic translation initiation factor 2 beta-like pseudogene MAP3K13 3q27 mitogen-activated protein kinase kinase kinase 13 MGC15397 3q28 similar to RIKEN cDNA 5730578N08 gene LIPH 3q27-q28 lipase, member H SENP2 3q28 lipase, member H IMP-2 3q28 IGF-II mRNA-binding protein 2 SFRS10 3q26.2-q27 splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) LOC344887 3q28 similar to RIKEN cDNA 1110025F24 ETV5 3q28 ets variant gene 5 (ets-related molecule) DGKG 3q27-q28 diacylglycerol kinase, gamma 90kDa
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
 mouth   highly
 stomach   highly
Endocrinepancreas    
Hearing/Equilibriumearinnercochlea highly
Reproductivemale systemprostate   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
  • N terminal kinase catalytic domain, hybrid between those of serine/threonine and tyrosine protein kinases,
  • a double leucine zipper domain
  • a C terminal SSEEEEGEVDSEVE sequence
  • conjugated PhosphoP
    mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY mixed lineage kinase family, serine/threonine protein kinase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
    text associated with membrane components
    basic FUNCTION activating the jun N-terminal pathway through activation of the map kinase kinase MAP2K7
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    JNK cascade
    a component dimerizing through its dual leucine-zipper motif
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    magnesium
    protein
  • interacts with the c-terminus of MAPK8IP1 through the kinase catalytic domain
  • binds PRDX3
  • associates with the IKK complex through the kinase domain
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS