basic FUNCTION
| serine/threonine protein kinase that may contribute to promoting microtubule instability, a hallmark of M phase entry |
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contributing to the TNF signaling pathway that activates JNK |
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required for mitogen activation of BRAF and cell proliferation |
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activates multiple mitogen-activated protein kinase (MAPK) pathways in response to growth factors, stresses and the pro-inflammatory cytokine, tumor necrosis factor (TNF) |
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regulates the MAPKinase pathway activating ERK, MAPK14 and JNK, in response to extracellular signals |
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scaffolding protein, involved in the formation of a multiprotein complex containing MAP3K11/BRAF/RAF1 |
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required for optimal activation of stress activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) signaling by TNFA |
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activates multiple MAPK pathways, including the JNK (c-Jun N-terminal kinase) pathway |
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crucial requirement in the migration of invasive breast cancer cells |
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induces luminal repopulation and suppresses the expression of the pro-apoptotic protein BCL2L11 in breast cancer |
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having both a proliferative and antiapoptotic role in the acquisition of a malignant phenotype in mammary epithelial cells |
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is an important regulator of MMP expression and invasion in ovarian cancer cells |
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plays a crucial role in compromising mitochondrial integrity and functions as a proapoptotic competence factor in the early stages of cytokine-induced pancreatic beta cell death |
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promotes saturated fatty acid-induced JNK activation and diet-induced metabolic dysfunction. |
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mitogen-activated protein kinase kinase kinase that activates multiple mitogen-activated protein kinase pathways and has been implicated in regulating proliferation in several cell types |
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is a critical factor controlling the activity of kinase networks that control the cellular responses to different concentrations of ROS |