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FLASH GENE
Symbol MAP3K10 contributors: npt/mct - updated : 27-10-2010
HGNC name mitogen-activated protein kinase kinase kinase 10
HGNC id 6849
Location 19q13.2      Physical location : 40.697.650 - 40.721.481
Synonym name
  • mixed lineage kinase 2, dual (tyr and ser:thr) specificity
  • MKN28 derived nonreceptor_type serine/threonine kinase
  • MKN28 kinase
  • mixed lineage kinase 2
  • Synonym symbol(s) MLK2, MST, MEKK10
    EC.number 2.7.1.25
    DNA
    TYPE functioning gene
    STRUCTURE 23.83 kb     10 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    TIMM50 19q13.2 translocase of inner mitochondrial membrane 50 homolog (yeast) DLL3 19q13.1-13.3 delta-like 3 (Drosophila) SELV 19q13.2 selenoprotein V FLJ38944 19q13.2 hypothetical protein FLJ38944 MGC20452 LOC390930 19 similar to Charot-Leyden crystal protein; Charcot-Leyden crystal protein; eosinophil lysophospholipase; lysolecithin acylhydrolase; galactin-10 PP13 19q13.1 placental protein 13 LOC390931 19 similar to placental protein 13-like protein LOC148003 19q13.2 similar to placental protein 13; galectin-13 LOC390932 19 similar to Eosinophil lysophospholipase (Charcot-Leyden crystal protein homolog) (Lysolecithin acylhydrolase) (CLC) (Galectin-10) PPL13 19q13.2 placental protein 13-like protein CLC 19q13.1 Charot-Leyden crystal protein LOC342900 19q13.2 hypothetical LOC342900 DYRK1B 19q12-q13.11 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B FBL 19q13.1 fibrillarin FCGBP 19q13.1 Fc fragment of IgG binding protein LOC388540 19 hypothetical gene supported by BX640962; NM_018457 PSMC4 19q13.11-q13.13 proteasome (prosome, macropain) 26S subunit, ATPase, 4 MGC43537 19q13.2 hypothetical protein MGC43537 LOC390933 19 similar to hypothetical protein FLJ36874 LOC163131 19q13.2 similar to BC331191_1 LOC284323 19q13.2 hypothetical protein LOC284323 MAP3K10 19q13.2 mitogen-activated protein kinase kinase kinase 10 FLJ30373 19q13.2 hypothetical protein FLJ30373 FLJ13265 19q13.2 hypothetical protein FLJ13265 AKT2 19q13.2 v-akt murine thymoma viral oncogene homolog 2 FLJ36888 19q13.2 hypothetical protein FLJ36888 PLD3 19q13.2 phospholipase D3 FLJ32818 PRX 19q13.13-13.2 periaxin SEI1 19q13.1-q13.2 periaxin RBT1 19q13.1-q13.2 periaxin BLVRB 19q13.13-q13.2 biliverdin reductase B (flavin reductase (NADPH)) SPTBN4 19q13.13 spectrin, beta, non-erythrocytic 4 LOC92799 19q13.2 hypothetical protein BC007653 LTBP4 19q13.1-q13.2 latent transforming growth factor beta binding protein 4 NUMBL 19q13-q13.2 numb homolog (Drosophila)-like ADCK4 19q13.2 aarF domain containing kinase 4 ITPKC 19q13.1 inositol 1,4,5-trisphosphate 3-kinase C FLJ41131 19q13.2 FLJ41131 protein SNRPA 19q13.2 small nuclear ribonucleoprotein polypeptide A
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    10 - 3453 - 954 - 1995 7731697
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   highly
    Nervousbrain    
    Reproductivefemale systemuteruscervix highly
     male systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervouscentral   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES basic
    STRUCTURE
    motifs/domains
  • SH3 N terminal motif
  • a catalytic domain (in MLK1 domain)
  • two leucine zipper domains
  • a basic sequence
  • a protein kinase domain
  • a C terminal proline-rich domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map3k10
    homolog to C.elegans F20b6.8
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • co-localizes with activated JNK along microtubules
  • localized both in the cytoplasm and cell nucleus
  • basic FUNCTION
  • induction of apoptosis
  • serine/threonine protein kinase involved in nerve growth factor (NGF) induced neuronal apoptosis
  • activating the JUN N-terminal pathway
  • playing a role in the neuronal death mechanism
  • role for MAP3K10 and the stress-signaling pathway at sites of clathrin activity in vesicle formation or trafficking
  • regulates NTRK2 expression through phosphorylation of an activation domain of TCF3
  • both hippocalcin and MAP3K10 may be associated with the pathogenesis of Parkinson disease
  • upstream activator of JNKs and activation of MAP3K10-mediated signaling cascades play roles in neurodegenerative and apoptotic mechanisms in the central nervous system
  • able to phosphorylate COPS2 in immune-kinase assays
  • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    JNK cascade
    a component
  • homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • normal huntingtin, NEUROD1, HAP1
  • interacting with TCF3 (enhances phosphorylation of the AD2 activation domain of TCF3)
  • interacting partner for the corepressor COPS2
  • clathrin is a binding partner for MAP3K10 in mammalian brain (clathrin binding requires a motif (LLDMD) located near the MLK2 C terminus, which is similar to "clathrin box" motifs important for binding of clathrin coat assembly and accessory proteins to the clathrin heavy chain)
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    upregulated in pancreatic ductal adenocarcinoma tissues and cell lines
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerdigestivepancreas
    targeting MAP3K10 is a potential strategy for the development of alternative therapies for pancreatic cancers
    ANIMAL & CELL MODELS