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FLASH GENE
Symbol MAP2K7 contributors: mct - updated : 12-03-2019
HGNC name mitogen-activated protein kinase kinase 7
HGNC id 6847
Location 19p13.2      Physical location : 7.968.764 - 7.979.362
Synonym name
  • C JUN N terminal kinase kinase 2
  • protein kinase, mitogen-activated,kinase 7
  • Synonym symbol(s) MKK7, MAPKK7, PRKMK7, JNKK2, MyD118
    EC.number 2.7.1.37/ 2.7.12.2
    DNA
    TYPE functioning gene
    STRUCTURE 8.00 kb     11 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Map pter - EEF2 - FUT3 - D19S216 - GTF2F1 - INSR - EMR1 - D19S812 - FCER2 - MAP2K7 - RPS28 - D19S413 - cen
    Authors Gene Map
    Physical map
    P114-RHO-GEF 19p13.3 angiopoietin-like 4 PEX11G 19p13.2 peroxisomal biogenesis factor 11 gamma FLJ35784 19p13.3 FLJ35784 protein ZNF358 19p13.3 zinc finger protein 358 MCOLN1 19p13.3-13.2 mucolipin 1 NTE 19p13.3-p13.2 mucolipin 1 KIAA1543 19p13.3-p13.2 mucolipin 1 XAB2 19p13.3 XPA binding protein 2 MGC41903 STXBP2 19p13.3-p13.2 syntaxin binding protein 2 RETN 19p13.3 resistin LOC199675 19p13.3 hypothetical protein LOC199675 TRAPPC5 19p13.3 trafficking protein particle complex 5 FCER2 19p13.3 Fc fragment of IgE, low affinity II, receptor for (CD23A) UNQ431 19p13.3 DTTR431 CD209 19p13 CD209 antigen CD209L 19p13.3 CD209 antigen-like LOC390879 19 similar to DTTR431 LOC115704 19p13.3 similar to ecotropic viral integration site 5; Neuroblastoma stage 4S gene LOC388499 19 similar to lysophospholipase II; acyl-protein thioesterase FLJ23420 19p13.3 hypothetical protein FLJ23420 MAP2K7 19p13.2 mitogen-activated protein kinase kinase 7 LOC388500 19 LOC388500 SNAPC2 19q13.3-p13.2 small nuclear RNA activating complex, polypeptide 2, 45kDa TIMM44 19p13.3-p13.2 translocase of inner mitochondrial membrane 44 homolog (yeast) ELAVL1 19p13.2 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R) CCL25 19p13.2 chemokine (C-C motif) ligand 25 FBN3 19p13 fibrillin 3 LASS4 19p13.3 LAG1 longevity assurance homolog 4 (S. cerevisiae) 8D6A 19p13.3-p13.2 LAG1 longevity assurance homolog 4 (S. cerevisiae) NDUFA7 19p13.2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 7, 14.5kDa RPS28 19p13.2 ribosomal protein S28 FLJ46061 19p13.3 FLJ46061 protein ANGPTL4 19p13.3 angiopoietin-like 4
    RNA
    TRANSCRIPTS type messenger
    text two isoforms produced by alternative splicing
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    11 splicing 3386 47 419 - 1997 9372971
    - splicing 3900 - 461 - 1998 9535930
    - - 1308 - 435 in various normal tissues, tumors, and in synoviocytes from rheumatoid and osteoarthritis patients 2006 9372971
  • can be phosphorylated and activated by MEKK1
  • Filamin A binds to an N-terminal region (residues 31-60) present in the MKK7gamma
  • importance of MKK7gamma1 in its ability to reverse basic cellular programmes by simply using JNKs as effectors
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a protein kinase domain
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • HOMOLOGY
    interspecies ortholog to Drosophila Dhep
    ortholog to C.elegans
    homolog to murine Map2k7
    homolog to F35c8.3
    Homologene
    FAMILY
  • MAP (mitogen-activated-protein) kinase family
  • Dual specificity protein kinase family
  • CATEGORY enzyme , tumor suppressor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,nucleus
    basic FUNCTION
  • activating JNK
  • involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses
  • works as a cytoplasmic anchoring protein for JNK1 in various types of cells, including human peripheral blood mononuclear cell (PBMC) T-cells
  • acts through the kinases JNK1 and JNK2, and this signaling pathway directly couples oncogenic and genotoxic stress to the stability of TP53, which is required for cell cycle arrest and suppression of epithelial cancers
  • is a vital molecular sensor to set a cellular anti-cancer barrier
  • MAP2K4 and MAP2K7 are required for optimal activation of JNKs in a synergistic fashion but MAP2K4 can also affect the second stress kinase pathway MAPK14
  • functions as a tumor suppressor for epithelial cancers of the lung, mammary gland and skin downstream of various oncogenes
  • CELLULAR PROCESS protein
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with DUSP19 to negatively regulate JNK pathway
  • interacting with GADD45B (could induce cardiomyocytes hypertrophic response and GADD45B could inhibit the enzymatic activity of MAP2K7 by contacting critical residues in the catalytic domain)
  • FLNA, FLNB and FLNC interact with MAP2K4 and MAP2K7, but not with JNK
  • ARR3 directly binds MAP2K7
  • MAP2K4 and MAP2K7 compete for ARR3 binding
  • ARR3 promotes MAPK10 phosphorylation by MAP2K7
  • stimulation of nTregs through TNFRSF18 initiates a signaling cascade that involves MAP2K7, MAPK8 phosphorylation, JUN activation, and the activation of NFKB1
  • cell & other
    REGULATION
    activated by phosphorylation
    FLNA (Filamin A enhances MAP2K7 activation and is important for synergistic stress-induced JNK activation)
    inhibited by CYLD
    Other MAP kinase in the JUNK pathway
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional       loss of function
    of the MAP2K7-JUN N-terminal kinase (JNK) signalling cascade may underlie some of the neurochemical changes and core symptoms in schizophrenia
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS