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Symbol MAP2K6 contributors: SGE/npt - updated : 14-09-2018
HGNC name mitogen-activated protein kinase kinase 6
HGNC id 6846
Location 17q24.3      Physical location : 67.410.837 - 67.538.462
Synonym name
  • protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
  • MAPK/ERK kinase
  • Synonym symbol(s) MKK6, MEK6, PRKMK6, SAPKK3
    EC.number 2.7.1.37, 2.7.12.2
    DNA
    TYPE functioning gene
    STRUCTURE 127.63 kb     29 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    text several alternatively spliced isoforms, with distinct tissue expression (Han)
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    12 - 1879 - 334 skeletal muscle, heart, liver, pancreas Inoue (2005)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveliver    
    Endocrinepancreas    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map2k6
    homolog to C.elegans R03g5.2
    intraspecies homolog to MAP2K3
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • serine/threonine kinase, controlling cell proliferation (cell cycle arrest)
  • involved in TNFA mediated endothelial SCYA2 (MCP1) expression
  • involved in BMP4-stimulated osteocalcin synthesis, as a positive regulator in osteoblasts
  • activating PRKMK8 and p38 kinase (MAPK) and required for ABL1 induced apoptosis
  • downregulates NADPH oxidase activity by enhancing Rac-GTPase activity (Harraz 2007)
  • with MAP3K7, constitute the p38 signalling pathway to participate to Osteoclasts differentiation by TNFSF11 through p65 phosphorylation and NFATC1 induction (Huang 2006)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • p38-dependent mRNA stabilization of 42 AU rich genes, some involved in macrophage activation
  • inducing SOCS3
  • stress activated kinase MAP2K6 acts as a repressor of UCP1 expression, suggesting that its inhibition promotes adipose tissue browning and increases organismal energy expenditure
  • cell & other
    REGULATION
    activated by UV, anisomycin and os miotic stock
    phosphorylation
    TNFA
    Other phosphorylated by MAP3K5 (Sturchler 2010)
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS