Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MAP2K5 contributors: mct/npt/pgu - updated : 27-03-2018
HGNC name mitogen-activated protein kinase kinase 5
HGNC id 6845
Location 15q23      Physical location : 67.835.020 - 68.099.451
Synonym name
  • MAP kinase kinase 5
  • dual specificity mitogen-activated protein kinase kinase 5
  • MAPK/ERK kinase 5
  • Synonym symbol(s) MEK5, PRKMK5, HsT17454, MAPKK5, MKK5
    EC.number 2.7.12.2
    DNA
    TYPE functioning gene
    STRUCTURE 264.43 kb     22 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    NOPE 15q22.2 glucuronyl C5-epimerase DPP8 15q22 dipeptidylpeptidase 8 HSPC121 15q22.2 butyrate-induced transcript 1 DKFZP564O1664 15q22.2 hypothetical protein DKFZp564O1664 SLC24A1 15q22 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 IRLB 15q22.2 solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 LOC388127 15 similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing protein) (Single-strand binding protein) (hnRNP core protein A1) (HDP) RAB11A 15q21.3-q22.31 RAB11A, member RAS oncogene family MEGF11 15q22.2 MEGF11 protein MGC4562 15q22.2 hypothetical protein MGC4562 FLJ20516 15q22.2 timeless-interacting protein MAP2K1 15q22.1-q22.33 mitogen-activated protein kinase kinase 1 LOC388128 15 similar to ribosomal protein L9; 60S ribosomal protein L9 SNAPC5 15q22.2 small nuclear RNA activating complex, polypeptide 5, 19kDa RPL4 15q22 ribosomal protein L4 FLJ10036 15q22.2 hypothetical protein FLJ10036 MADH6 15q21-q22 MAD, mothers against decapentaplegic homolog 6 (Drosophila) LOC390597 15 similar to leucine zipper-EF-hand containing transmembrane protein 1 MADH3 15q21-q22 MAD, mothers against decapentaplegic homolog 3 (Drosophila) DKFZP586N0721 15q22.31 DKFZP586N0721 protein FLJ11506 15q22.31 hypothetical protein FLJ11506 FLJ12476 15q22.31 hypothetical protein FLJ12476 LOC145853 15q22.31 similar to ENSANGP00000021391 MAP2K5 15q22.2-q22.31 mitogen-activated protein kinase kinase 5 LOC390598 15 similar to RIKEN cDNA C230094B15 LOC388129 15 hypothetical gene supported by BC033162 LOC390599 15 similar to 40S ribosomal protein S15a PIAS1 15q21.3-q22.1 protein inhibitor of activated STAT, 1 MGC4809 15q22.2 serologically defined breast cancer antigen NY-BR-20 CLN6 15q23 ceroid-lipofuscinosis, neuronal 6, late infantile, variant FEM1B 15q22 fem-1 homolog b (C. elegans) ITGA11 15q22.3-q23 integrin, alpha 11 CORO2B 15q22-q23 coronin, actin binding protein, 2B ANP32A 15q22-q23 acidic (leucine-rich) nuclear phosphoprotein 32 family, member A FLJ11722 15q22.31 hypothetical protein FLJ11722 LOC390600 15 similar to RIKEN cDNA 2810413N20 NOX5 15q22.31 NADPH oxidase, EF hand calcium-binding domain 5 SPESP1 15q22.31 sperm equatorial segment protein 1 FLJ33768 15q22.31 hypothetical protein FLJ33768 GLCE 15q22.31 glucuronyl C5-epimerase MPRG 15q22.31 glucuronyl C5-epimerase KIF23 15q22-q23 kinesin family member 23 RPLP1 15q22 ribosomal protein, large, P1 LOC388130 15 LOC388130
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    22 - 2381 50.1 448 - 1995 7759517
    21 - 2334 - 438 - 1995 7759517
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • 11 conserved kinase subdomains in the catalytic domain
  • a PB1 domain in the N-terminus, they form a heterodimer via PB1-PB1 domain interaction that was reported to be indispensable to the activation of MAP2K5
  • HOMOLOGY
    interspecies homolog to murine Map2k5
    homolog to C.elegans Y54E10BL.6
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    basic FUNCTION
  • serine/threonine protein kinase
  • CCM2L and CCM2 cooperate to regulate the activity of MAP3K3
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
  • activation of MAP2K5/MAPK7 signaling strongly inhibits endothelial cells migration and results in massive morphological changes
  • YAP1 promotes myogenic differentiation via the MAP2K5-MAPK7 pathway
  • a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ERK5/PRKM7/MAP kinase
  • interacting with MAP3K3 (activate the MAPK7 signal pathway by phosphorylating and activating MEK2K5)
  • activates MAPK7 and induces KLF4 to modulate TNF responses in dermal microvascular endothelial cells
  • REST promoted primordial germ cells (PGCs) survival via regulation of the MAP2K5 expression
  • MAPK7/MAP2K5 pathway mediates fluid shear stress induced RUNX2 expression in osteoblast differentiation
  • XIAP directly interacts with MAP3K3 and competes with PB1 domain-mediated binding to MAP2K5
  • activation of the MAPK7/MAP2K5 pathway with CSF1R is required for osteoclast differentiation, which may induce differentiation through the induction of FOS
  • both CCM2L and CCM2 interfere with MAP3K3 activation and its ability to phosphorylate MAP2K5, a downstream target
  • cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    associated with aggressive prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS