basic FUNCTION
| may be involved in JNK cascade, protein amino acid phosphorylation, signal transduction |
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having serine/threonine kinase activity |
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playing a role in the suppression of metastatic colonization in ovarian cancer |
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MAP2K4 and MAP2K7 are required for optimal activation of JNKs in a synergistic fashion but MAP2K4 can also affect the second stress kinase pathway MAPK14 |
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antagonizes cardiomyocyte hypertrophy |
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new role for MAP2K4 in regulating GJA1 expression and preventing hypertrophy-associated arrhythmogenesis |
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regulates GJA1 transcription most likely by virtue of two AP-1 binding sites in the GJA1 proximal promoter region |
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critical cardiac protector preventing hypertrophy-associated ventricular arrhythmias through restriction of GJA1 remodeling |
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MAPK7 and MAP2K4 could play an important role in osteosarcoma tumorigenesis |
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plays a crucial role in the stress-activated signal cascade and is enzymatically regulated by ligand or substrate binding, and/or post-translational modification |
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is essential during embryogenesis and involved in a variety of physiological and pathological processes |
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has not always a definite function, but rather triggers a cellular reaction in concert with other modulators |