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FLASH GENE
Symbol MAP2K3 contributors: mct/npt - updated : 06-02-2008
HGNC name mitogen-activated protein kinase kinase 3
HGNC id 6843
Location 17q11.2      Physical location : 21.187.967 - 21.218.549
Synonym name
  • MAP kinase kinase 3
  • MAPK/ERK kinase 3
  • dual specificity mitogen activated protein kinase kinase 3
  • Synonym symbol(s) MEK3, MKK3, PRKMK3, MAPKK3, SAPKK2
    EC.number 2.7.1.37/ 2.7.12.2
    DNA
    TYPE functioning gene
    STRUCTURE 30.58 kb     12 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC390775 17 similar to ubiquitin specific protease 6; tre-2 oncogene; hyperpolymorphic gene 1 LOC388353 17 similar to AF038169 protein LOC347720 LOC256223 17p11.2 similar to CDRT15 protein LOC390776 17 similar to RIKEN cDNA E130119J17 LOC257468 17p11.2 similar to Homeobox protein Meis3 (Meis1-related protein 2) LOC342646 17p11.2 similar to differentially expressed in FDCP 8 LOC390777 17 similar to RIKEN cDNA 2610318I15 LOC388354 17 similar to PTD016 protein LOC284202 17p11.2 similar to stearoyl-CoA desaturase; acyl-CoA desaturase; fatty acid desaturase; delta-9-desaturase LOC339184 17p11.2 similar to hypothetical protein FLJ36492 LOC284203 17p11.2 similar to Ribonuclease H1 (RNase H1) (Ribonuclease H type II) USP22 17p13.1 ubiquitin specific protease 22 DKFZp566O084 17p12 DKFZP566O084 protein C17orf35 17p11.1 chromosome 17 open reading frame 35 MGC33894 17p11.2 transcript expressed during hematopoiesis 2 MAP2K3 17q11.2 mitogen-activated protein kinase kinase 3 KCNJ12 17p11.1 potassium inwardly-rectifying channel, subfamily J, member 12 LOC388355 17 similar to 60S ribosomal protein L21 LOC388356 17 LOC388356 LOC388357 17 similar to bB329D4.2.1 (novel protein similar to a truncated nuclear receptor co-repressor 1 (NCOR1) (retinoid X receptor interacting protein 13), isoform 1) LOC388358 17 hypothetical gene supported by BC042812 UBBP4 17p11.2 ubiquitin B pseudogene 4 LOC284123 17p11.2 hypothetical gene supported by BC031617
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 2304 - 318 - Derijard, Raingeaud (1996)
    - splicing 2160 - 352 - Han
    12 splicing 2319 - 347 - Han, Raingeaud (1996)
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • serine-threonine protein kinases, catalytic domain
  • a docking site, a stretch of about 20 amino acids immediately on the C-terminal side of the MAPKK catalytic domain (Takekawa 2005)
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Map2k3
    homolog to C.elegans R03g5.2
    intraspecies homolog to MAP2K6
    Homologene
    FAMILY
  • protein kinase superfamily
  • STE Ser/Thr protein kinase family
  • MAP kinase kinase subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • serine/threonine kinase controling cell proliferation
  • regulating MAPK14 in fibroblast-like synoviocytes (Inoue 2005)
  • have differential roles in osteoclastogenesis as MAP2K6 from bone marrow precursors (Huang 2006)
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by phosphorylation
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    homozygously, in lung cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS