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FLASH GENE

Symbol

MAP1S

contributors: mct - updated : 23-09-2011

HGNC name	microtubule-associated protein 1S
HGNC id	15715

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	19p13.11      Physical location : 17.830.302 - 17.845.324
Genatlas name	BPY2 interacting protein 1
Synonym name	chromosome 19 open reading frame 5
	VCY2 interacting protein 1
	microtubule-associated protein 1S
	RASSF1A-binding protein 1
Synonym symbol(s)	FLJ10669, C19orf5, VCY2IP-1, VCY2IP1, BPY2IP1, RABP1, MAP8

DNA

TYPE	like-sequence
STRUCTURE	15.02 kb     7 Exon(s)

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_018174 7 - 3278 - 1059 - 2011 21262964 MAP1SSC - - - - - - 2011 21262964 short chain associates with mitochondria in addition to microtubules and causes irreversible aggregation of dysfunctional mitochondria resulting in cell death

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Homo sapiens Digestive mouth tongue     highly Nervous brain       moderately Homo sapiens Reproductive male system testis     predominantly

cells

System Cell Pubmed Species Stage Rna symbol Reproductive germ cell Reproductive spermatozoa

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

embryo, perinatal

Text	during late embryonic and neonatal periods, and subsequently decrease moderately to remain constant into adulthood

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	N-terminus playing a role in anchoring the microtubule-organizing center to the centrosomes
	an arginine-rich potential RNA-binding motif
	a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1b to microtubules
	three hallmark domains of the microtubule-associated protein 1 family but hardly any additional sequences
	two microtubule-associated protein domains
	C-terminus interacts with mitochondria-associated DNA binding protein, LRPPRC, in liver cells

isoforms

Precursor

synthesized as a precursor protein that is partially cleaved into heavy and light chains in a tissue-specific manner

HOMOLOGY

intraspecies

homolog to microtubule-associated protein MAP1B

Homologene

FAMILY

MAP1a/MAP1b family, microtubule-associated protein family

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,endoplasmic reticulum
	intracellular,cytoplasm,cytosolic
	intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
	intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
	intracellular,nucleus
text	localized to the centrosome throughout the cell cycle in a manner dependent on its microtubule-associated protein domains
	specifically associates with microtubules stabilized by paclitaxel or RASSF1A
	distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest
	appears on the microtubular spindle during mitosis and reversibly accumulates during mitotic arrest
	localizes to the microtubule-organizing centers during microtubule regrowth after nocodazole washout

basic FUNCTION	may play a role in the cytoskeletal changes that accompany neurite extension
	required for the recruitment of RASSF1 to the spindle poles and for its inhibition of APC-CDC20 activity during mitosis
	DNA binding protein similar to microtubule-associated proteins tau and MAP2
	may function to anchor RASSF1A to the centrosomes
	can potentially provide an underlying mechanism for the frequent centrosome and microtubule abnormalities detected in several cancers
	role in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance
	may play a general role in autophagy regulation in all tissues
	positively regulate autophagy and, particularly, mitophagy
	link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

heavy and light chains (light chain binds, bundles, and stabilizes microtubules and binds to actin, the heavy chain appears to regulate light chain activity)

INTERACTION

DNA	selectively binding double strand DNA

RNA

small molecule

protein	interacting with natural paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A
	interacting with mitochondria-associated DNA binding protein, LRPPRC, in liver cells
	interacting with BPY2
	interact with NADH dehydrogenase I and cytochrome oxidase I
	interacting with NDUFAF2 (some changes of NDUFAF2 expression modulate activity of apoptotic caspases 3/7, suggesting that this protein may indirectly participate in apoptosis)
	bound to prestin (SLC26A5)
	MAP1S isoforms may act as a linker to bridge autophagy components not only with the microtubular cytoskeleton through interacting with MAP1LC3A isoforms but also directly to mitochondria, one of the major substrates of autophagy through the interaction with LRPPRC

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

ablation of the Map1s gene in mice causes impairment in both basal autophagy for clearance of abnormal mitochondria and nutritive stress-induced autophagy for nutrient recycling via the Bcl-2/xL/P27 pathway