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FLASH GENE
Symbol MAP1S contributors: mct - updated : 23-09-2011
HGNC name microtubule-associated protein 1S
HGNC id 15715
Location 19p13.11      Physical location : 17.830.302 - 17.845.324
Genatlas name BPY2 interacting protein 1
Synonym name
  • chromosome 19 open reading frame 5
  • VCY2 interacting protein 1
  • microtubule-associated protein 1S
  • RASSF1A-binding protein 1
  • Synonym symbol(s) FLJ10669, C19orf5, VCY2IP-1, VCY2IP1, BPY2IP1, RABP1, MAP8
    DNA
    TYPE like-sequence
    STRUCTURE 15.02 kb     7 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    7 - 3278 - 1059 - 2011 21262964
    - - - - - - 2011 21262964
  • short chain
  • associates with mitochondria in addition to microtubules and causes irreversible aggregation of dysfunctional mitochondria resulting in cell death
  • EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly Homo sapiens
    Digestivemouthtongue  highly
    Nervousbrain   moderately Homo sapiens
    Reproductivemale systemtestis  predominantly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivegerm cell
    Reproductivespermatozoa
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period embryo, perinatal
    Text during late embryonic and neonatal periods, and subsequently decrease moderately to remain constant into adulthood
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • N-terminus playing a role in anchoring the microtubule-organizing center to the centrosomes
  • an arginine-rich potential RNA-binding motif
  • a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1b to microtubules
  • three hallmark domains of the microtubule-associated protein 1 family but hardly any additional sequences
  • two microtubule-associated protein domains
  • C-terminus interacts with mitochondria-associated DNA binding protein, LRPPRC, in liver cells
  • isoforms Precursor synthesized as a precursor protein that is partially cleaved into heavy and light chains in a tissue-specific manner
    HOMOLOGY
    intraspecies homolog to microtubule-associated protein MAP1B
    Homologene
    FAMILY MAP1a/MAP1b family, microtubule-associated protein family
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
    intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
    intracellular,nucleus
    text
  • localized to the centrosome throughout the cell cycle in a manner dependent on its microtubule-associated protein domains
  • specifically associates with microtubules stabilized by paclitaxel or RASSF1A
  • distributed broadly across the mitotic spindle and reversibly accumulated during reversible mitotic arrest
  • appears on the microtubular spindle during mitosis and reversibly accumulates during mitotic arrest
  • localizes to the microtubule-organizing centers during microtubule regrowth after nocodazole washout
  • basic FUNCTION
  • may play a role in the cytoskeletal changes that accompany neurite extension
  • required for the recruitment of RASSF1 to the spindle poles and for its inhibition of APC-CDC20 activity during mitosis
  • DNA binding protein similar to microtubule-associated proteins tau and MAP2
  • may function to anchor RASSF1A to the centrosomes
  • can potentially provide an underlying mechanism for the frequent centrosome and microtubule abnormalities detected in several cancers
  • role in bridging microtubules and mitochondria with autophagic and mitophagic initiation, maturation, trafficking, and lysosomal clearance
  • may play a general role in autophagy regulation in all tissues
  • positively regulate autophagy and, particularly, mitophagy
  • link between MAP1S-enhanced autophagy and suppression of genomic instability and tumorigenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component heavy and light chains (light chain binds, bundles, and stabilizes microtubules and binds to actin, the heavy chain appears to regulate light chain activity)
    INTERACTION
    DNA selectively binding double strand DNA
    RNA
    small molecule
    protein
  • interacting with natural paclitaxel-like microtubule stabilizer and candidate tumor suppressor RASSF1A
  • interacting with mitochondria-associated DNA binding protein, LRPPRC, in liver cells
  • interacting with BPY2
  • interact with NADH dehydrogenase I and cytochrome oxidase I
  • interacting with NDUFAF2 (some changes of NDUFAF2 expression modulate activity of apoptotic caspases 3/7, suggesting that this protein may indirectly participate in apoptosis)
  • bound to prestin (SLC26A5)
  • MAP1S isoforms may act as a linker to bridge autophagy components not only with the microtubular cytoskeleton through interacting with MAP1LC3A isoforms but also directly to mitochondria, one of the major substrates of autophagy through the interaction with LRPPRC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • ablation of the Map1s gene in mice causes impairment in both basal autophagy for clearance of abnormal mitochondria and nutritive stress-induced autophagy for nutrient recycling via the Bcl-2/xL/P27 pathway