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FLASH GENE
Symbol MAP1LC3B contributors: mct - updated : 24-12-2016
HGNC name microtubule-associated protein 1 light chain 3 beta
HGNC id 13352
Location 16q24.2      Physical location : 87.425.800 - 87.438.379
Synonym name
  • autophagy-related ubiquitin-like modifier LC3 B
  • MAP1 light chain 3-like protein 2
  • Synonym symbol(s) MAP1A/1BLC3, LC3B, MAP1ALC3, ATG8F
    DNA
    TYPE functioning gene
    STRUCTURE 15.22 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    regulatory sequence Promoter
    Binding site   cAMP
    text structure
  • a cyclic AMP response element binding site for ATF4, facilitating autophagy, and resulting in MAP1LC3B upregulation
  • MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 2304 14.56 125 - 2014 25051050
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Nervousbrain    
    Reproductivemale systemtestis   
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    cell lineage forming neurons
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • LC3 interaction region (LIR)
  • mono polymer heteromer , polymer
    HOMOLOGY
    interspecies homolog to yeast S.cerevisiae Apg8
    Homologene
    FAMILY
  • MAP1LC3 family, GABARAP subfamily
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    text
  • a key component of the autophagosomal membrane
  • basic FUNCTION
  • involved in the filamentous cross-bridging between microtubules and other cytoskeletal elements
  • may play a role in breast cancer development
  • mediates phagophore elongation whereas GABARAPL2 acts downstream
  • MAP1LC3B and ATG5 are not required for initiation of autophagy but mediate phagophore expansion and autophagosome formation
  • with MAP1LC3A, are involved in elongation of the phagophore membrane whereas the GABARAP/GABARAPL2 subfamily is essential for a later stage in autophagosome maturation
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • exerts a protective function during the pathogenesis of pulmonary hypertension (PH), through the regulation of hypoxic cell proliferation
  • MAP1LC3B, ATG5 and ATG12 are involved in mitochondrial quality control after oxidative damage, and to cellular longevity
  • conjugated MAP1LC3B deacetylation, which was partly mediated by HDAC6, is involved in autophagic degradation during serum starvation
  • is indispensable for selective autophagy of SQSTM1 but not basal autophagy
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS development , nervous system
    text neurogenesis
    PATHWAY
    metabolism
    signaling
    a component
  • a subunit of both MAP1A and MAP1B
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to tubulin
  • hyperoxia-induced MAP1LC3B activation regulates the FAS apoptotic pathway and thus confers cytoprotection in lung epithelial cells (interaction of MAP1LC3B and FAS pathways requires CAV1)
  • modulation of MAP1LC3B levels through inhibition of histone deacetylation at the MAP1LC3B locus may be a viable option to increase basal autophagy in nondividing terminally differentiated cells
  • MAP1LC3B, GABARAP and GABARAPL1 are novel interactors of MAPK15, a MAP kinase involved in cell proliferation and transformation
  • PGRMC1 binds to key components of the autophagy machinery (MAP1LC3B) and is required for the degradative activity of autophagy
  • APP interacts with MAP1LC3B via OPTN/optineurin and is degraded by an autophagic process mediated by the PRKAA1 pathway
  • RAF1/MEK/ERK can regulate cellular levels of MAP1LC3B and SQSTM1 at expression levels
  • FUNDC1 interacting with microtubule-associated protein light chain 3 beta (MAP1LC3B) through its LC3 interaction region (LIR)
  • MAP1LC3B, GABARAPL2 and GABARAP might play specific roles in different autophagic processes
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • MAP1LC3B binds to TRIM5 via the alpha-helical coiled-coil region
  • cell & other
    REGULATION
    induced by hypoxia
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • reliable marker of poor prognosis in triple-negative breast cancers
  • Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    inhibition of autophagy is a promising therapeutic strategy for TNBC patients
    ANIMAL & CELL MODELS