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Symbol MAP1LC3A contributors: mct - updated : 01-10-2016
HGNC name microtubule-associated protein 1 light chain 3 alpha
HGNC id 6838
Location 20q11.22      Physical location : 33.134.691 - 33.148.149
Synonym name
  • microtubule associated proteins 1A and B, common light chain LC3
  • MAP1 light chain 3-like protein 1
  • autophagy-related ubiquitin-like modifier LC3 A
  • MAP1A/1B light chain 3 A
  • Synonym symbol(s) MAP1LC3, MAP1ALC3, MAP1BLC3, LC3, LC3A, ATG8E
    TYPE virus associated
    STRUCTURE 13.46 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CBFA2T2 20q11.21-q11.23 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 APBA2BP 20q11.21 amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein C20orf144 20q11.21 chromosome 20 open reading frame 144 E2F1 20q11 E2F transcription factor 1 PXMP4 20q11.21 peroxisomal membrane protein 4, 24kDa ZNF341 20q11.21 zinc finger protein 341 RPL31P2 20q11.2 ribosomal protein L31 pseudogene 2 C20orf178 20q11.22 chromosome 20 open reading frame 178 TPM5P 20q11.2 tropomyosin 5, pseudogene RALY 20q11.21-q11.23 RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow) EIF2S2 20pter-q12 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa LOC391244 20 similar to ribosomal protein S2; 40S ribosomal protein S2 XPOTP1 20q11.21 exportin, tRNA (nuclear export receptor for tRNAs) pseudogene 1 ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1030 - 121 - 2012 22249245
  • LC3Av1
  • frequently inactivated at the transcriptional level in various human cancer cell lines, and its inactivation was due to aberrant DNA methylation in esophageal squamous cell carcinoma (ESCC) cell lines and primary tumors
  • functions in autophagy and further, LC3Av1 may be crucial in carcinogenesis
  • 5 - 990 - 125 - 2012 22249245
  • LC3Av2
    Type widely
    constitutive of
       expressed in (based on citations)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousnerve   highly
    Visualeye   highly
    cell lineage
    cell lines
    at STAGE
  • produced by the proteolytic cleavage after the conserved C-terminal Gly residue
    interspecies ortholog to rat Map1lc3
    FAMILY GABARAP subfamily
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    basic FUNCTION
  • plays an essential role in autophagy, which is involved in the bulk degradation of cytoplasmic components by the lysosomal system
  • may play a role in breast cancer development
  • role in the regulation of Rho signaling and in the reorganization of the actin cytoskeleton
  • microtubule-associated protein light chain 3, specific autophagic marker in mammalian cells, that is processed from the cytosolic form (LC3-I) to the membrane-bound form (LC3-II)
  • with MAP1LC3B, are involved in elongation of the phagophore membrane whereas the GABARAP/GABARAPL2 subfamily is essential for a later stage in autophagosome maturation
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • involved in the lipid droplet formation regardless of the bulk degradation, and has two pivotal roles in cellular homeostasis mediated by autophagy and lipid metabolism
  • with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage
  • modulation of MAP1LC3A levels through inhibition of histone deacetylation at the MAP1LC3A locus may be a viable option to increase basal autophagy in nondividing terminally differentiated cells
  • GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are not essential for autophagosome formation but are critical for autophagosome-lysosome fusion
  • novel roles for FKBP8 and MAP1LC3A, which act together to induce mitophagy
    a component
    small molecule
  • interacting with FOXO3 (FOXO3 controls the transcription of autophagy-related genes, including MAP1LC3 and BNIP3
  • MAP1LC3A is a novel regulatory protein interacting with AKAP13
  • FYCO1 binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
  • MAP1S isoforms may act as a linker to bridge autophagy components not only with the microtubular cytoskeleton through interacting with MAP1LC3A isoforms, but also directly to mitochondria
  • hypoxia induced dephosphorylation of FUNDC1 and enhanced its interaction with MAP1LC3A for selective mitophagy
  • strong evidence that transcriptional repression plays a major role in regulating Atg8/LC3 levels, and this up-regulation results in an increase in the size of the autophagosome
  • although AP2 and PICALM bind to MAP1LC3A, they do not seem to be direct substrates of autophagy
  • interaction between MAP1LC3A and AP2M1 as well as PICALM showed a significant increase triggered by starvation
  • at mitochondria, ULK1 interacts with FUNDC1, phosphorylating it at serine 17, which enhances FUNDC1 binding to MAP1LC3A
  • DACT1 increases autophagosome formation as indicated by elevated puncta formation of MAP1LC3A, ATG14 and ZFYVE1 (Double FYVE-containing protein 1)
  • AMBRA1 is able to induce mitophagy via MAP1LC3A binding, regardless of PARK2 and SQSTM1
  • autophagy protein MAP1LC3A/Atg8 directly interacts with the nuclear lamina protein LMNB1 (lamin B1), and binds to LMN/lamin-associated chromatin domains (LADs)
  • FUNDC1, mediate selective removal of damaged or superfluous mitochondria through their specific interaction with MAP1LC3A
  • GABARAP subfamily members, GABARAP, GABARAPL1, GABARAPL2, MAP1LC3A, MAP1LC3B, are primary contributors to PINK1/Parkin mitophagy and starvation autophagy
  • KLC1 may potentially compete with MAP1LC3A, a key component for autophagosome formation, to interact with FUNDC1
  • FKBP8 efficiently recruits lipidated MAP1LC3A to damaged mitochondria in a LIR-dependent manner
  • cell & other