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FLASH GENE
Symbol MAP1LC3A contributors: mct - updated : 01-10-2010
HGNC name microtubule-associated protein 1 light chain 3 alpha
HGNC id 6838
Location 20q11.22      Physical location : 33.134.691 - 33.148.149
Synonym name
  • microtubule associated proteins 1A and B, common light chain LC3
  • MAP1 light chain 3-like protein 1
  • autophagy-related ubiquitin-like modifier LC3 A
  • MAP1A/1B light chain 3 A
  • Synonym symbol(s) MAP1LC3, MAP1ALC3, MAP1BLC3, LC3, LC3A, ATG8E
    DNA
    TYPE functioning gene
    STRUCTURE 13.46 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    CBFA2T2 20q11.21-q11.23 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 APBA2BP 20q11.21 amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein C20orf144 20q11.21 chromosome 20 open reading frame 144 E2F1 20q11 E2F transcription factor 1 PXMP4 20q11.21 peroxisomal membrane protein 4, 24kDa ZNF341 20q11.21 zinc finger protein 341 RPL31P2 20q11.2 ribosomal protein L31 pseudogene 2 C20orf178 20q11.22 chromosome 20 open reading frame 178 TPM5P 20q11.2 tropomyosin 5, pseudogene RALY 20q11.21-q11.23 RNA binding protein (autoantigenic, hnRNP-associated with lethal yellow) EIF2S2 20pter-q12 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa LOC391244 20 similar to ribosomal protein S2; 40S ribosomal protein S2 XPOTP1 20q11.21 exportin, tRNA (nuclear export receptor for tRNAs) pseudogene 1 ASIP 20q11.21 agouti signaling protein, nonagouti homolog (mouse) AHCY 20cen-q13.1 S-adenosylhomocysteine hydrolase ITCH 20q11.22-23 itchy homolog E3 ubiquitin protein ligase (mouse) CDC42P1 20q11.22 cell division cycle 42 pseudogene 1 FDXP1 20cen-q13.1 ferredoxin pseudogene 1 FLJ38773 20q11.22 hypothetical protein FLJ38773 DNCL2A 20q12-q13.1 dynein, cytoplasmic, light polypeptide 2A MAP1LC3A 20cen-q13 microtubule-associated protein 1 light chain 3 alpha CDC91L1 20q11.21 CDC91 cell division cycle 91-like 1 (S. cerevisiae) NCOA6 20q11 nuclear receptor coactivator 6 HMG4L 20q11.21 high-mobility group (nonhistone chromosomal) protein 4-like GGTL3 20pter-p13 gamma-glutamyltransferase-like 3 ACAS2 20q11.2-q12 acetyl-Coenzyme A synthetase 2 (ADP forming) GSS 20q11.21 glutathione synthetase MYH7B 20q11.21 myosin, heavy polypeptide 7B, cardiac muscle, beta TRPC4AP 20q11.23 transient receptor potential cation channel, subfamily C, member 4 associated protein C20orf31 20q11.23 chromosome 20 open reading frame 31 PROCR 20q11.21 protein C receptor, endothelial (EPCR) MMP24 20q11.2 matrix metalloproteinase 24 (membrane-inserted) ITGB4BP 20q11.2 integrin beta 4 binding protein C20orf128 20q11.21 chromosome 20 open reading frame 128 C20orf44 20q11.23 chromosome 20 open reading frame 44 GDF5 20q11.2 growth differentiation factor 5 (cartilage-derived morphogenetic protein-1) CEP2 20pter-q12 centrosomal protein 2 LOC343705 20q11.23 similar to beta-galactoside alpha-2,3-sialyltransferase C20orf173 20q11.22 chromosome 20 open reading frame 173 SDBCAG84 20pter-q12 serologically defined breast cancer antigen 84
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1030 - 121 - PMID: 178044
    5 - 990 - 125 - PMID: 17804493
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Nervousnerve   highly
    Visualeye   highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • produced by the proteolytic cleavage after the conserved C-terminal Gly residue
  • HOMOLOGY
    interspecies ortholog to rat Map1lc3
    Homologene
    FAMILY
    CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic,vesicle
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • plays an essential role in autophagy, which is involved in the bulk degradation of cytoplasmic components by the lysosomal system
  • may play a role in breast cancer development
  • role in the regulation of Rho signaling and in the reorganization of the actin cytoskeleton
  • microtubule-associated protein light chain 3, specific autophagic marker in mammalian cells, that is processed from the cytosolic form (LC3-I) to the membrane-bound form (LC3-II)
  • with MAP1LC3B, are involved in elongation of the phagophore membrane whereas the GABARAP/GABARAPL2 subfamily is essential for a later stage in autophagosome maturation
  • MAP1LC3A and MAP1LC3B and GABARAPs are essential for autophagosome formation and therefore suggest a dual role for individual members of this protein family
  • involved in the lipid droplet formation regardless of the bulk degradation, and has two pivotal roles in cellular homeostasis mediated by autophagy and lipid metabolism
  • with SLC30A4, MAP1LC3A and CASP3 might play a role in the pathophysiology of recurrent neonatal seizure-induced acute and long-term brain damage
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with FOXO3 (FOXO3 controls the transcription of autophagy-related genes, including MAP1LC3 and BNIP3
  • FYCO1 binds to both MAP1LC3A, PtdIns(3)P and RAB7A, and contains a domain responsible for microtubule plus end-dependent transport
  • MAP1S isoforms may act as a linker to bridge autophagy components not only with the microtubular cytoskeleton through interacting with MAP1LC3A isoforms, but also directly to mitochondria
  • although AP2 and PICALM bind to MAP1LC3A, they do not seem to be direct substrates of autophagy
  • interaction between MAP1LC3A and AP2M1 as well as PICALM showed a significant increase triggered by starvation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS