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FLASH GENE
Symbol MAP1A contributors: shn/npt - updated : 15-11-2009
HGNC name microtubule-associated protein 1A
HGNC id 6835
Location 15q15.3      Physical location : 43.809.805 - 43.823.817
Synonym name
  • modifier of tubby hearing
  • proliferation-related protein p80
    • Synonym symbol(s) MTAP1A, MOTH1, MAP1L, FLJ77111, MAP-1A
    DNA
    TYPE functioning gene
    STRUCTURE 14.01 kb     6 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status confirmed
    Map cen - D15S968 - D15S641 - MAP1A - D15S132 - D15S1006 - qter
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    6 - 10275 306.5 2803 brain, enriched in mature dendrites Szebenyi (2005)
    EXPRESSION
    Type restricted
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   highly
     spinal cord   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal lowly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Nervousneuron
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • heavy chain and light chain LC2
  • caldesmon domain
    • HOMOLOGY
    interspecies ortholog to Map1a, Rattus norvegicus
    ortholog to MAP1A, Pan troglodytes
    ortholog to Mtap1a, Mus musculus
    Homologene
    FAMILY
  • microtubule associated protein family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    basic FUNCTION
  • involved in microtubule assembly
  • involved in the filamentous cross-bridging between microtubules and other skeletal elements
  • implicated in dendritic differentiation and maintenance
  • important for dendritic growth and activity-driven dendritic remodelling (Szebenyi 2005)
  • a role in early events of spinal cord development
  • mediates interactions between microtubules and actin, and also binds components of the postsynaptic density (Conde 2009)
    • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS
    text cell shape and cell size control
    PATHWAY
    metabolism
    signaling
    a component
  • 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cyclic AMP (cAMP)-binding domain of exchange protein directly activated by cyclic AMP 1 RAPGEF3, to enhance Rap1 GTPase activity and cell adhesion
  • disrupted-In-Schizophrenia 1 (DISC1)
  • adaptor protein 1 (AP-1)
  • postsynaptic density-93 (PSD-93)
  • tubulin
  • G-actin and F-actin
  • MAP1A and MAP1B interact with SNTA1 in the central and peripheral nervous system
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to hearing loss
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS