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FLASH GENE
Symbol MAN2C1 contributors: mct/npt - updated : 15/102008
HGNC name mannosidase, alpha, class 2C, member 1
HGNC id 6827
Location 15q11-q13      Physical location : 75.648.134 - 75.660.941
Synonym name
  • mannosidase, alpha A, cytoplasmic
  • alpha-D-mannoside mannohydrolase
  • alpha mannosidase 6A8B
  • Synonym symbol(s) MANA, MAN6A8, MANA1, MGC87979, DKFZp686E23167
    EC.number 3.2.1.24
    DNA
    TYPE functioning gene
    STRUCTURE 12.81 kb     26 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    Physical map
    FLJ32855 15q23 hypothetical protein FLJ32855 CYP11A1 15q23-q24 cytochrome P450, family 11, subfamily A, polypeptide 1 SEMA7A 15q22.3-q23 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A MGC14421 DRIL2 15q24 sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A CLK3 15q24 CDC-like kinase 3 FLJ21128 15q23 hypothetical protein FLJ21128 CYP1A1 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 1 CYP1A2 15q22-q24 cytochrome P450, family 1, subfamily A, polypeptide 2 CSK 15q23-q25 c-src tyrosine kinase LMAN1L 15q22-23 lectin, mannose-binding, 1 like DKFZP434C131 15q23 DKFZP434C131 protein SCAMP2 15q23-q25 secretory carrier membrane protein 2 MPI 15q22-qter mannose phosphate isomerase FLJ00005 COX5A 15q25 cytochrome c oxidase subunit Va Rpp25 15q23 RNase P protein subunit p25 SCAMP5 15q22.33 RNase P protein subunit p25 MDS018 15q23 hypothetical protein MDS018 LOC390605 15 similar to stromal cell-derived factor 2 precursor DKFZP434H132 15q23 DKFZP434H132 protein LOC390606 15 similar to nucleolar phosphoprotein Nopp34 LOC388136 15 LOC388136 LOC388137 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC390607 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC145801 15q23 similar to Acidic leucine-rich nuclear phosphoprotein 32 family member B (PHAPI2 protein) (Silver-stainable protein SSP29) (Acidic protein rich in leucines) FLJ20452 15q23 hypothetical protein FLJ20452 NEIL1 15q23 nei endonuclease VIII-like 1 (E. coli) MAN2C1 15q11-q13 mannosidase, alpha, class 2C, member 1 SIN3A 15q24 SIN3 homolog A, transcriptional regulator (yeast) PTPN9 15q22.33 protein tyrosine phosphatase, non-receptor type 9 RNUT1 15q22.33 RNA, U transporter 1 C15orf12 15q24 chromosome 15 open reading frame 12 MGC32065 15q23 hypothetical protein MGC32065 CSPG4 15q23 chondroitin sulfate proteoglycan 4 (melanoma-associated) MGC48986 15q23 hypothetical protein MGC48986 LOC388138 15 similar to Dynamin-1 (D100) (Dynamin, brain) (B-dynamin) LOC390608 15 similar to peptidyl-Pro cis trans isomerase LOC390609 15 similar to Golgi autoantigen, golgin subfamily A member 6 (Golgin linked to PML) (Golgin-like protein) LOC92912 15q23 hypothetical protein LOC92912 FBXO22 15q24.1 F-box only protein 22 LOC145957 15q23 neuregulin 4 FLJ38190 15q23-q24.1 hypothetical protein FLJ38190 ETFA 15q23-q25 electron-transfer-flavoprotein, alpha polypeptide (glutaric aciduria II)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    26 - 3254 - 1040 - Olsen (2006)
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunespleen   highly
    Nervousbrain   highly
    Reproductivemale systemtestis  highly
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic tail
  • a single transmembrane segment (TM1)
  • a large C-terminal catalytic domain
  • HOMOLOGY
    interspecies ortholog to murine Man2c1
    ortholog to rattus man2c1
    Homologene
    FAMILY
  • glycosyl hydrolase 38 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text type II transmembrane protein
    basic FUNCTION
  • involved in hydrolysis of terminal, non-reducing alpha-D- mannose residues in alpha-D-mannosides
  • involved in the degradation of oligomannosides derived from dolichol intermediates and the degradation of newly synthesized glycoproteins
  • playing a role in T-cell functioning
  • alpha-mannosidase, involved in the processing of free oligosaccharides that are formed in the cytosol
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS