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FLASH GENE
Symbol MAN2B2 contributors: mct - updated : 24-01-2014
HGNC name mannosidase, alpha, class 2B, member 2
HGNC id 29623
Location 4p16.1      Physical location : 6.576.901 - 6.624.188
Synonym name
  • related to alpha-D mannosidase
  • epididymis-specific alpha-mannosidase precursor
  • Synonym symbol(s) KIAA0935
    EC.number 3.2.1.24
    DNA
    TYPE functioning gene
    STRUCTURE 47.29 kb     19 Exon(s)
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    19 - 4242 - 1009 - 2009 19722277
    EXPRESSION
    Type ubiquitous
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Digestiveliver   highly
    Nervousbrain   highly
    Reproductivefemale systemovary  highly
    Respiratorylung   highly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Nervouscentral   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a glycosyl hydrolases family 38 N-terminal domain
  • a glycosyl hydrolases family 38 C-terminal domain
  • conjugated GlycoP
    isoforms Precursor a peptide signal from the 1st to 23th aa
    HOMOLOGY
    intraspecies homolog to alpha-D mannosidase
    Homologene
    FAMILY glycosylhydrolase 38 family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    intracellular,cytoplasm,organelle,lysosome
    text secreted
    basic FUNCTION
  • hydrolase activity on terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides
  • may be fonctionning in tandem with chitobiase (CTBS) in N-glycan catabolism
  • MAN2B1, MAN2B2 act in a complementary fashion on different glycosidic linkages, to effect glycan degradation in the lysosome
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS