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FLASH GENE
Symbol MAN1C1 contributors: npt/ - updated : 04-09-2004
HGNC name mannosidase, alpha, class 1C, member 1
HGNC id 19080
Location 1p36.11      Physical location : 25.943.958 - 26.111.258
Synonym name
  • 1,2-alpha-mannosidase IC
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
    • Synonym symbol(s) HMIC, MAN1A3, pp6318, MAN1C
    EC.number 3.2.1.113
    DNA
    TYPE functioning gene
    STRUCTURE 167.30 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC391020 1 similar to Interferon-induced transmembrane protein 3 (Interferon-inducible protein 1-8U) P29 1p36.13-p35.1 GCIP-interacting protein p29 DJ465N24.2.1 1p36.13-p35.1 hypothetical protein dJ465N24.2.1 SMP1 1p36.11 hypothetical protein dJ465N24.2.1 RHCE 1p36.1 Rhesus blood group, CcEe antigens LOC388606 1 similar to Succinate dehydrogenase [ubiquinone] cytochrome B small subunit, mitochondrial precursor (CybS) (Succinate-ubiquinone reductase membrane anchor subunit) (QPS2) (CII-4) (Succinate dehydrogenase complex subunit D) (Succinat RHD 1p36.1 Rhesus blood group, D antigen LOC388607 1 similar to RhCE protein LOC388608 1 similar to mutant membrane protein RhCe FLJ10747 1p36.11 hypothetical protein FLJ10747 ARH MAN1C1 1p35 mannosidase, alpha, class 1C, member 1 SEPN1 1p36.13 selenoprotein N, 1 LOC56181 1p35.3 hypothetical protein RP1-317E23 MGC2603 1p35.3 hypothetical protein MGC2603 MPRA 1p36.11 hypothetical protein MGC2603 FLJ32206 1p35.3 hypothetical protein FLJ32206 STMN1 1p36.11 stathmin 1/oncoprotein 18 LOC388609 1 LOC388609 PAFAH2 1p34.2 platelet-activating factor acetylhydrolase 2, 40kDa EXTL1 1p36.1 exostoses (multiple)-like 1 SLC30A2 1p35.3 solute carrier family 30 (zinc transporter), member 2 RNF28 1p34-p33 ring finger protein 28 LOC149420 1p35.3 casein kinase FLJ14050 1p35.3 hypothetical protein FLJ14050 ZT86 1p35.3 zinc finger protein CNK1 1p35.3 zinc finger protein CATSPER4 1p35.3 cation channel, sperm associated 4 LOC391021 1 similar to secreted acid phosphatase 2 (SAP2) DKFZP434L0117 1p35.3 hypothetical protein DKFZp434L0117 MRPS6P1 1p35 mitochondrial ribosomal protein S6 pseudogene 1 SH3BGRL3 1p35-p34.3 SH3 domain binding glutamic acid-rich protein like 3 SOC 1p35.3 SH3 domain binding glutamic acid-rich protein like 3 CDW52 1p36 CDW52 antigen (CAMPATH-1 antigen)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3201 70.8 630 - Hosokawa (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic domain
  • a transmembrane domain
  • a luminal domain
  • two N glycosylation sites
  • a proline rich stem region
  • the catalytic site
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • glycosyl hydrolase 47 family
    • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the
    • oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
  • involved in the maturation of Asn-linked oligosaccharides
    • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
    • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS