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FLASH GENE
Symbol MAN1C1 contributors: npt/ - updated : 04-09-2004
HGNC name mannosidase, alpha, class 1C, member 1
HGNC id 19080
Location 1p36.11      Physical location : 25.943.958 - 26.111.258
Synonym name
  • 1,2-alpha-mannosidase IC
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IC
  • Synonym symbol(s) HMIC, MAN1A3, pp6318, MAN1C
    EC.number 3.2.1.113
    DNA
    TYPE functioning gene
    STRUCTURE 167.30 kb     15 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    14 - 3201 70.8 630 - Hosokawa (2007)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart    
    Digestiveintestinelarge intestinecolon  
     liver    
    Lymphoid/Immunespleen    
     thymus    
    Nervousbrain    
    Reproductivefemale systemovary   
     male systemprostate   
     male systemtestis   
    Urinarykidney    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Blood/Hematopoieticleukocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a cytoplasmic domain
  • a transmembrane domain
  • a luminal domain
  • two N glycosylation sites
  • a proline rich stem region
  • the catalytic site
  • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
  • glycosyl hydrolase 47 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    basic FUNCTION
  • involved in the hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the
  • oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
  • involved in the maturation of Asn-linked oligosaccharides
  • CELLULAR PROCESS protein, post translation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate
    signaling
    N-glycosylation
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
  • Ca2+
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS