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FLASH GENE
Symbol MAN1A2 contributors: mlc/np - updated : 02-11-2007
HGNC name mannosidase, alpha, class 1A, member 2
HGNC id 6822
Location 1p13.1      Physical location : 117.910.084 - 118.068.320
Synonym name
  • alpha-1,2-mannosidase IB
  • mannosyl-oligosaccharide 1,2-alpha-mannosidase IB
  • Synonym symbol(s) MAN1B
    EC.number 3.2.1.113
    DNA
    TYPE functioning gene
    STRUCTURE 158.00 kb     13 Exon(s)
    Genomic sequence alignment details
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked   status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    13 - 5388 73 641 - Gregory (2006)
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivepharynx   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Reproductivefemale systemplacenta  highly
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Lymphoid/Immunelymphocyte
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a short cytoplasmic tail
  • a single transmembrane segment (TM1)
  • a large COOH-terminal catalytic domain
  • a potential N glycosylation site
  • HOMOLOGY
    interspecies homolog to murine alpha1.2 Mannosidase 13
    Homologene
    FAMILY glycosyl hydrolase family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,Golgi
    text type II transmembrane protein
    basic FUNCTION
  • involved in processing of Asp-linked (N) glycans
  • involved in hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide
  • Man(9)(GlcNAc)(2)
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule cofactor,
    Ca2+
    protein
    cell & other
    REGULATION
    inhibited by both 1-deoxymannojirimycin and kifunensine
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS