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FLASH GENE
Symbol MAML3 contributors: mct/pgu - updated : 31-08-2013
HGNC name mastermind-like 3 (Drosophila)
HGNC id 16272
Location 4q31.1      Physical location : 140.637.545 - 141.075.233
Synonym name
  • expanded repeat domain, CAG/CTG 3
  • trinucleotide repeat containing 3
  • CAG repeat containing (glia-derived nexin I alpha)
  • polyglutamine rich
  • Synonym symbol(s) KIAA1816, GDN, MAM2, CAGH3, ERDA3, MAM-2, MAML2, TNRC3
    DNA
    TYPE functioning gene
    STRUCTURE 437.69 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC152620 4q28.3 similar to telomeric repeat binding factor 1 isoform 2; Telomeric repeat binding factor 1; telomeric repeat binding protein 1 LOC391701 4 similar to ribosomal protein S23 SLC7A11 4q28-q32 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 LOC152594 4q28.3 similar to ART-4 protein CCRN4L 4q28.3 CCR4 carbon catabolite repression 4-like (S. cerevisiae) ELF2 4q28 E74-like factor 2 (ets domain transcription factor) LOC389224 4 hypothetical gene supported by AK097799 OSAP 4q31.1 ovary-specific acidic protein NDUFC1 4q28.2-q28.3 NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa TBDN100 4q31.1 transcriptional coactivator tubedown-100 RAB33B 4q28 RAB33B, member RAS oncogene family SET7 4q28 SET domain-containing protein 7 MGST2 4q28-q31 microsomal glutathione S-transferase 2 MAML3 4q28 mastermind-like 3 (Drosophila) SCOC 4q28.3 short coiled-coil protein LOC391702 4 similar to ribosomal protein L14; 60S ribosomal protein L14 CLGN 4q28.3-q31.1 calmegin LOC152586 4q31.1 similar to RIKEN cDNA 4933434I20 MGC10084 4q31.1 hypothetical protein MGC10084 UCP1 4q28-q31 uncoupling protein 1 (mitochondrial, proton carrier) KIAA0882 4q31.1 KIAA0882 protein LOC389225 4 LOC389225 LOC389226 4 similar to ring finger protein 130; g1-related zinc finger protein RNF150 4q31.1 ring finger protein 150 LOC389227 4 LOC389227 ZNF330 4q31.1-q31.2 LOC389227 LOC389228 4 similar to GRIK2 protein IL15 4q31 interleukin 15 INPP4B 4q31.11 inositol polyphosphate-4-phosphatase, type II, 105kDa USP38 4q31.1 ubiquitin specific protease 38 GAB1 4q31.4-q13.5 GRB2-associated binding protein 1
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 7086 121.5 1133 - 2002 1238615
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systemovary   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch
  • two consensus sites for SUMOylation at Lysine217 and Lysine299
  • a transcriptional activation domain in the C terminus
  • HOMOLOGY
    interspecies ortholog to murine Maml3 (86 pc)
    Homologene
    FAMILY
  • mastermind family
  • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • putative regulator for notch signaling
  • possibly involved in regulating neurodevelopment or neuroplasticity
  • transcriptional regulators in Notch signaling
  • engagement of Mastermind (Mam) is essential for Notch signaling, and MAML1, MAML2, MAML3 have distinct roles
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS