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FLASH GENE
Symbol MAML3 contributors: mct/pgu - updated : 31-08-2013
HGNC name mastermind-like 3 (Drosophila)
HGNC id 16272
Location 4q31.1      Physical location : 140.637.545 - 141.075.233
Synonym name
  • expanded repeat domain, CAG/CTG 3
  • trinucleotide repeat containing 3
  • CAG repeat containing (glia-derived nexin I alpha)
  • polyglutamine rich
    • Synonym symbol(s) KIAA1816, GDN, MAM2, CAGH3, ERDA3, MAM-2, MAML2, TNRC3
    DNA
    TYPE functioning gene
    STRUCTURE 437.69 kb     5 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    5 - 7086 121.5 1133 - 2002 1238615
    EXPRESSION
    Type widely
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivemouthtongue  highly
    Lymphoid/Immunelymph node   highly
    Nervousbrainhindbraincerebellum  
    Reproductivefemale systemovary   
    Urinarykidney    
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved basic domain in their N termini that binds to the ankyrin repeat domain of Notch
  • two consensus sites for SUMOylation at Lysine217 and Lysine299
  • a transcriptional activation domain in the C terminus
    • HOMOLOGY
    interspecies ortholog to murine Maml3 (86 pc)
    Homologene
    FAMILY
  • mastermind family
    • CATEGORY regulatory , DNA associated , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    basic FUNCTION
  • putative regulator for notch signaling
  • possibly involved in regulating neurodevelopment or neuroplasticity
  • transcriptional regulators in Notch signaling
  • engagement of Mastermind (Mam) is essential for Notch signaling, and MAML1, MAML2, MAML3 have distinct roles
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS