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FLASH GENE
Symbol MALL contributors: npt/ - updated : 01-03-2007
HGNC name mal, T-cell differentiation protein-like
HGNC id 6818
Location 2q13      Physical location : 110.841.451 - 110.874.143
Synonym name
  • BENE protein
  • MAL-like
  • Synonym symbol(s) BENE, MGC4419
    DNA
    TYPE functioning gene
    STRUCTURE 30.20 kb     4 Exon(s)
    MAPPING cloned Y linked N status confirmed
    regionally located 6kb distal from NPHP1 (close to NPHP1)
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 3071 17.2 153 - de Marco (2001)
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Lymphoid/Immunetonsils    
    Urinarykidney    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Epithelial    
    Lymphoid    
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Urinaryepithelial cell
    cell lineage
    cell lines endothelial-like cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • four transmembrane segments
  • three consensus caveolin-1 interaction motifs
  • HOMOLOGY
    intraspecies homolog to T cell differentiation protein
    homolog to MAL,MAL2
    Homologene
    FAMILY
  • MAL proteo-lipid family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text glycosphingolipid and cholesterol-enriched membrane micro domains (raft)
    basic FUNCTION
  • involved in a raft-mediated trafficking in endothelial cells (de Marco 2001)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS