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FLASH GENE
Symbol MALAT1 contributors: mct - updated : 28-01-2011
HGNC name metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)
HGNC id 29665
Location 11q13.1      Physical location : 65.265.232 - 65.273.937
Synonym name PRO1073 protein, alpha gene
Synonym symbol(s) PRO1073, MALAT-1
DNA
TYPE small rna
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type untranslated small nuclear
EXPRESSION
Rna function
  • long nuclear-retained regulatory RNA (nrRNA), having a role in Alternative splicing regulation, by modulating the levels of active serine/arginine (SR) proteins
  • expressed in numerous tissues and is highly abundant in neurons
  • may regulates synapse formation by modulating the expression of genes involved in synapse formation and/or maintenance
  • Type
       expressed in (based on citations)
    organ(s)
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    HOMOLOGY
    interspecies ortholog to murine Malat1
    Homologene
    FAMILY
    CATEGORY
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text long MALAT1 transcript localizes to nuclear speckles, the small RNA is found exclusively in the cytoplasm
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral fusion      
    with TFEB in t(6;11) (p21;q13) in renal tumor
    constitutional     --over  
    in placenta previa and might be involved in regulating trophoblast invasion during the development of advanced invasive placentation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductiveuterus
    may serve as a therapeutic target in the prevention of human cervical cancer
    ANIMAL & CELL MODELS