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FLASH GENE

Symbol

MAGMAS

contributors: mct/npt - updated : 18-08-2010

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	16p13.3      Physical location : -
Genatlas name	mitochondria-associated protein involved in granulocyte-macrophage colony-stimulating factor signal transduction
Synonym name	mitochondria-associated granulocyte macrophage CSF signaling molecule
	magmas-like protein
	colony-stimulating factor signal transduction
Synonym symbol(s)	CGI-136, TIMM16

DNA

TYPE	functioning gene
STRUCTURE	11.05 kb     5 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_016069 5 - 527 NP_057153 - 125 - Jubinsky (2005)

EXPRESSION

Type

widely

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart         Digestive intestine large intestine colon   highly   pharynx       highly Lymphoid/Immune lymph node       highly Nervous brain           nerve cranial nerve optic nerve     Visual eye anterior segment         eye lens

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Membrane serous membrane pericardium     Muscular striatum skeletal

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text	during the developmental stages upregulated in muscle, testis, intestinal mucosa and liver (Sinha 2010)

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

HOMOLOGY

interspecies

ortholog to S.cerevisiae Pam16

Homologene

FAMILY

CATEGORY

signaling

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm,organelle,mitochondria,inner
	intracellular,cytoplasm,organelle,membrane
text	localizes into mitochondria and is peripherally associated with inner mitochondrial membrane in yeast and humans (Sinha 2010)

basic FUNCTION	involved in GM-CSF signal transduction
	central role in protein import and mitochondria biogenesis (Sinha 2010)
	functions as a ‘signaling molecule’ and perhaps controls anaerobic metabolism, resistance to apoptosis or altered growth sensitivity in mammalian system (Sinha 2010)
	peripheral mitochondrial inner-membrane protein that is exposed to the matrix space and lacks multi-spanning transmembrane segments in the primary structure (Sinha 2010)

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

MAGMAS:DNAJC19 subcomplex is associated with TIMM23 complex and thus regulates mitochondrial import process (Sinha 2010)

INTERACTION

DNA

RNA

small molecule

protein

stable interaction between MAGMAS and DNAJC19 that plays a crucial role in tethering of DNAJC19 at the translocon and perhaps regulating human import motor activity (Sinha 2010)

cell & other

REGULATION

induced by

GM-CSF

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in prostate cancer

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS