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FLASH GENE
Symbol MAGI3 contributors: mct - updated : 11-12-2014
HGNC name membrane associated guanylate kinase, WW and PDZ domain containing 3
HGNC id 29647
Location 1p13.2      Physical location : 113.933.474 - 114.228.535
Genatlas name membrane-associated guanylate kinase-related (MAGI-3)
Synonym symbol(s) MAGI-3
DNA
TYPE functioning gene
STRUCTURE 295.46 kb     23 Exon(s)
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
21 - 7221 - 1125 - 2004 15195140
21 - 6536 - 1481 - 2004 15195140
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Hearing/Equilibriumear   highly
Nervousbrainlimbic systemhippocampusdentate gyrus  Homo sapiens
 brainforebraincerebral cortex   Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousastrocyte Homo sapiens
Nervousneuron Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a guanylate-kinase-like region
  • six PDZ and two WW domains
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane,junction,tight
        intracellular
    intracellular,nucleus
    basic FUNCTION
  • involved in intracellular signaling cascade
  • playing a possible role as a scaffolding molecule that links receptor tyrosine phosphatase with its substrates at the plasma membrane
  • functioning as a scaffold protein for frizzled-4(FZD4) and VANGL2 and regulates the JNK signaling cascade
  • is a negative regulator of LPA(2) signaling
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • with RPTP beta
  • interacting with VANGL2
  • has a role in efficient trafficking of TGFA to the cell surface in polarized epithelial cells (
  • interacts directly with LPAR2 and regulates the ability of LPAR2 to activate Erk and RHOA
  • both TP53 and MAGI3 represent effective targets for oncogenic E6, but the mechanisms by which E6 mediates TP53 and MAGI3 degradation are distinct with respect to the involvement of ubiquitination prior to proteasomal degradation
  • MAGI3 regulates ADRB2-mediated ERK activation through the physical interaction between ADRB2 and MAGI3
  • competes with SLC9A3R2 to negatively regulate LPA2 receptor signaling in colon cancer cells
  • co-expression with MAGI3 was found to potentiate signaling to ERK by constitutively active BAI1 in a manner that was dependent on the PDZ-binding motif of the receptor
  • MAGI1, -2, and -3 all contain WW domains and were confirmed as PRRG4-binding proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS