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FLASH GENE
Symbol MAGEE1 contributors: npt/ - updated : 15-10-2005
HGNC name melanoma antigen family E, 1
HGNC id 24934
Location Xq13.3      Physical location : 75.648.045 - 75.651.744
Synonym name
  • alpha-dystrobrevin-associated MAGE protein
  • hepatocellular carcinoma-associated protein 1
  • MAGE-E1 antigen
  • dystrobrevin-associated MAGE protein
  • Synonym symbol(s) HCA1, DAMAGE, KIAA1587, CT10, HCA587, MAGEC2
    DNA
    TYPE functioning gene
    STRUCTURE 3.63 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status provisional
    Physical map
    LOC266694 Xq27.1 embryonic ectoderm development pseudogene SOX3 Xq27.1 SRY (sex determining region Y)-box 3 CDR1 Xq27.1-q27.2 cerebellar degeneration-related protein 1, 34kDa SPANXB1 Xq27.1 SPANX family, member B1 dJ507I15.1 Xq27.1 ribosomal protein L36a pseudogene LDOC1 Xq27.2 leucine zipper, down-regulated in cancer 1 SPANXC Xq27.1 SPANX family, member C NDUFB3P5  NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa pseudogene 5 SPANXA1 Xq27.1 sperm protein associated with the nucleus, X chromosome, family member A1 LOC389897 X hypothetical gene supported by BC042039 SPANXE Xq27.1 SPANX family, member E SPANXD Xq27.1 SPANX family, member D MAGEC3 Xq27.2 melanoma antigen, family C, 3 MAGEC1 Xq26 melanoma antigen, family C, 1 LOC392554 X similar to melanoma antigen, family A, 10; melanoma-associated antigen 10; MAGE-10 antigen LOC392555 X similar to Melanoma-associated antigen E1 (MAGE-E1 antigen) (MAGE-C2 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen CT10) LOC139075 Xq27.2 similar to Melanoma-associated antigen E1 (MAGE-E1 antigen) (MAGE-C2 antigen) (Hepatocellular carcinoma-associated antigen 587) (Cancer-testis antigen CT10) MAGEE1 Xq27 melanoma antigen, family E, 1, cancer/testis specific LOC139067 Xq27.3 hypothetical LOC139067 MYCL3 Xq27.2 v-myc myelocytomatosis viral oncogene homolog 3 pseudogene (avian) SLITRK4 Xq27.3 SLIT and NTRK-like family, member 4 LOC389898 X similar to ubiquitin-conjugating enzyme E2N
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 3628 103 957 - -
    EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrainlimbic systemhippocampus highly
    Urinarybladder   lowly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Muscularstriatumskeletal  
    Nervousperipherous   
    cells
    SystemCellPubmedSpeciesStageRna symbol
    NervousPurkinje cell
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a potential nuclear localization signal
  • 30 12-amino acid repeats
  • two MAGE homology domains
  • HOMOLOGY
    interspecies ortholog to murine Magee1
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a signaling role in brain, muscle, and peripheral nerve (Albrecht 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS