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FLASH GENE
Symbol MAGEC2 contributors: mct - updated : 16-10-2015
HGNC name melanoma antigen family C, 2
HGNC id 13574
Location Xq27.2      Physical location : 141.290.128 - 141.293.076
Synonym name
  • melanoma antigen, family E, 1, cancer/testis specific
  • melanoma-associated antigen E1
  • cancer/testis antigen 10
  • hepatocellular carcinoma-associated antigen 587
  • MAGE-C2 antigen
  • Synonym symbol(s) CT10, MAGE-C2, MGE1, MAGEE1, HCA587, MGC13377
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 2.95 kb     3 Exon(s)
    MAPPING cloned Y linked N status provisional
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 2008 41 373 - 2013 23096706
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Nervousbrain   moderately
    Reproductivemale systemtestis  predominantly
    Respiratorylung   moderately
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / Hematopoieticbone marrow   
    Connective    
    cell lineage
    cell lines testis and liver cancer cell lines, glioma cell lines
    fluid/secretion blood
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a conserved MAGE Homology Domain
  • HOMOLOGY
    interspecies homolog to C.elegans T01D3.6B
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • tumor antigen
  • can promote tumor growth by phosphorylation of TRIM28-Ser824 and by enhancement of DNA damage repair
  • has a role in breast cancer metastasis through inducing epithelial-mesenchymal transition
  • TP53-independent role of MAGEC2 in promoting the survival of myeloma cells
  • is involved in SCF complex and increases the stability of cyclin E in tumor cells
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds TRIM28, a scaffolding protein that regulates DNA repair
  • MAGEC2 is a new negative regulator of ZMYND11
  • MAGEC2 binds directly to the RING domain protein RBX1, and participates in Skp1-Cullin1-F box protein (SCF) complex
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
  • MAGEC2/CT-10 may be a good candidate for peptide vaccination in patients with hepatocellular carcinoma
  • Marker
  • expression of MAGEC1/CT7 and MAGEC2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes
  • Therapy target
    SystemTypeDisorderPubmed
    cancerhemopathy 
    MAGEC2-specific immunotherapies have the potential to eradicate the most malignant cells within the myeloma tumour bulk leading to durable clinical responses
    cancerreproductivebreast
    targeting MAGEC2 may provide a novel therapeutic strategy for breast cancer treatment
    cancerreproductiveprostate
    potential target for adjuvant and palliative immunotherapy in patients with prostate cancer
    ANIMAL & CELL MODELS