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FLASH GENE
Symbol MAGEC1 contributors: mct/npt - updated : 07-07-2008
HGNC name melanoma antigen, family C, 1
HGNC id 6812
Location Xq26      Physical location : 140.991.641 - 140.997.185
Synonym name cancer/testis antigen 7.1
Synonym symbol(s) CT7, MAGE-C1, MGC39366
DNA
TYPE functioning gene
SPECIAL FEATURE component of a cluster
STRUCTURE 5.00 kb     4 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked N status provisional
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 4279 123.6 1142 - Andrade (2008)
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis   
Skin/Tegumentskin    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone   
cell lineage
cell lines significant proportion of tumors of various histological types
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a mage domain
  • HOMOLOGY
    Homologene
    FAMILY
  • melanoma antigen gene (MAGE) family
  • CATEGORY immunity/defense , antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • tumor antigen reconized by cytoxic T lymphocytes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • expression of MAGEC1/CT7 and MAGEC2/CT10 in osteolytic lesions of myeloma patients can be used for diagnostic, prognostic, as well as immunotherapeutic purposes
  • Therapy target
    ANIMAL & CELL MODELS