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FLASH GENE
Symbol MAGEB4 contributors: mct - updated : 20-05-2020
HGNC name melanoma antigen, family B, 4
HGNC id 6811
Location Xp21.2      Physical location : 30.260.056 - 30.262.295
Synonym name
  • cancer/testis antigen family 3, member 6
  • Synonym symbol(s) MGB4, MGC33144
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, overlapping, gene in gene
    text
  • clustered with other MAGEB genes on chromosome Xp22-p21
  • ending in the first intron of MAGEB1
  • STRUCTURE 2.19 kb     1 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    1 - 2188 - 346 - 2017 28401488
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    one mage domain
    HOMOLOGY
    intraspecies paralog to MAGEB1
    paralog to MAGEB2
    paralog to MAGEB3
    paralog to MAGEB5
    paralog to MAGEB6
    Homologene
    FAMILY MAGEB family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • MAGEA5, MAGEA8, MAGEB4 and MAGEB6 may have roles as tumor suppressors in the occurrence and development of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
    a mage domain
    HOMOLOGY
    intraspecies paralog to MAGEB1
    paralog to MAGEB2
    paralog to MAGEB3
    paralog to MAGEB5
    paralog to MAGEB6
    Homologene
    FAMILY MAGEB gene family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION acting as a tumor antigen
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional germinal mutation      
    single-base substitution (c.1041A>T) in the X-linked MAGEB4 gene was identified as a no-stop mutation, associated with non-syndromic male infertility
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
  • aberrant expression patterns of MAGEB4 in teratocarcinoma cells can be considered as specific teratocarcinoma biomarkers promoted the malignant phenotype
  • MAGEA3, MAGEB4, and ODF4 may be particularly useful for diagnostic and surveillance of bladder transitional cell carcinoma (TCC) in the form of a multi-biomarker panel
  • Therapy target
    ANIMAL & CELL MODELS