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FLASH GENE
Symbol MAGEB2 contributors: np/ - updated : 07-07-2008
HGNC name melanoma antigen family B, 2
HGNC id 6809
Location Xp21.2      Physical location : 30.233.674 - 30.238.204
Synonym name
  • DSS/AHC critical interval gene,from MAGE superfamily 6
  • cancer/testis antigen family 3, member 2
  • MAGE-B2 antigen
  • Synonym symbol(s) DAM6, MGB2, MGC26438, MAGE-XP-2, CT3.2
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    text clustered with other MAGEB genes on chromosome Xp22-p21
    STRUCTURE 4.53 kb     2 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    LOC347543 Xp22.11 similar to 60S ribosomal protein L7 HMGA1L1 Xp22 high mobility group AT-hook 1-like 1 LOC139420 Xp22.11 similar to KIAA1387 protein RDXP2 Xp22.12 radixin pseudogene 2 FLJ32742 Xp22.11 hypothetical protein FLJ32742 LOC347442 Xp22.11 similar to H326 FLJ32965 Xp22.11 hypothetical protein FLJ32965 LOC392434 X similar to melanoma antigen LOC392435 X similar to melanoma antigen LOC392436 X similar to melanoma antigen MAGE LOC340569 Xp22.11 pseudogene of origin recognition complex, subunit 1-like LOC139425 Xp22.11 similar to H326 IL1RAPL1 Xp22.1-p21.3 interleukin 1 receptor accessory protein-like 1 MAGEB2 Xp21.3 melanoma antigen, family B, 2 MAGEB3 Xp21.3 melanoma antigen, family B, 3 MAGEB4 Xp21.3 melanoma antigen, family B, 4 MAGEB1 Xp21.3 melanoma antigen, family B, 1 NR0B1 Xp21.3 nuclear receptor subfamily 0, group B, member 1 FLJ11577 Xp21.3 hypothetical protein FLJ11577 LOC392437 X similar to hypothetical protein GK Xp22.3-p21.3 glycerol kinase TAB3 Xp21.3 TAK1-binding protein 3 FTHL17 Xp21 ferritin, heavy polypeptide-like 17 DMD Xp21.3-p21.2 dystrophin (muscular dystrophy, Duchenne and Becker types) LOC392438 X hypothetical gene supported by NM_004607
    regionally located localized in the DSS (dosage-sensitive sex reversal) critical region
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    2 - 1628 - 319 - -
    EXPRESSION
    Type
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis   
    cell lineage
    cell lines in a significant fraction of tumors of various histological types
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • one mage domain
  • HOMOLOGY
    intraspecies paralog to MAGEB1
    paralog to MAGEB3
    paralog to MAGEB4
    paralog to MAGEB5
    paralog to MAGEB6
    Homologene
    FAMILY
  • MAGEB family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • involved in tumor growth and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by a demethylation process in tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS