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FLASH GENE
Symbol MAGEB1 contributors: mct/npt - updated : 07-07-2008
HGNC name melanoma antigen, family B, 1
HGNC id 6808
Location Xp21.3      Physical location : 30.261.847 - 30.270.154
Synonym name
  • DSS/AHC critical interval MAGE superfamily 10
  • cancer/testis antigen 3.1
  • MAGE-XP antigen
  • Synonym symbol(s) DAM10, MAGEL1, MAGE-Xp, MGC9322, CT3.1
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster, overlapping, gene in gene
    text
  • clustered with other MAGEB members on chromosome Xp22-p21
  • promoter region is included within the coding exon of MAGEB4
  • STRUCTURE 8.00 kb     4 Exon(s)    5 Copie(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    regionally located localized in the DSS (dosage-sensitive sex reversal) critical region
    RNA
    TRANSCRIPTS type messenger
    text Variants 1, 2 and 3 encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - splicing 1865 39 347 - Monaco, Ross (2005)
    encoding the same protein by the same last exon
    - splicing 1722 39 347 - Monaco, Ross (2005)
  • lacking three 5' exons but having an alternate 5' exon compared to variant 1
  • encoding the same protein by the same last exon
  • - splicing 1782 39 347 - Monaco, Ross (2005)
  • lacking an exon in the 5' region
  • encoding the same protein by the same last exon
  • EXPRESSION
    Type restricted
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivesalivary gland    
    Reproductivemale systemtestis   
    Skin/Tegumentskin    
    cell lineage
    cell lines a significant fraction of tumors of various histological types
    fluid/secretion
    at STAGE
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    interspecies homolog to C.elegans T07A9.7
    intraspecies paralog to MAGEB2
    paralog to MAGEB3
    paralog to MAGEB4
    paralog to MAGEB5
    paralog to MAGEB6
    Homologene
    FAMILY
  • human melanoma antigen,family B
  • MAGEB gene family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • acting as a tumor antigen
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by a demethylating process in tumors
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma and lung carcinomas
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS