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FLASH GENE
Symbol MAGEA9 contributors: mct - updated : 23-03-2009
HGNC name melanoma antigen family A, 9
HGNC id 6807
Location Xq28      Physical location : 148.663.313 - 148.869.394
Synonym name
  • MAGE-9 antigen
  • melanoma-associated antigen 9
  • cancer/testis antigen family 1, member 9
  • Synonym symbol(s) MAGE9, MAG9, CT1.9, MGC8421, MAGEA9B
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 5.81 kb     4 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    FMR1 Xq27.3 fragile X mental retardation 1 FLJ25736 LOC286397 Xq28 similar to Ferritin heavy chain (Ferritin H subunit) LOC389899 X similar to HS1 binding protein LOC347509 Xq28 similar to ribosomal protein L7-like 1 FMR2 Xq28 fragile X mental retardation 2 IDS Xq27.3-q28 iduronate 2-sulfatase (Hunter syndrome) IDSP1 Xq28 iduronate 2-sulfatase pseudogene 1 LOC91966 Xq28 hypothetical protein LOC91966 LOC347512 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LW-1 Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) FAM11A Xq28 similar to Heat shock transcription factor, Y-linked (Heat shock transcription factor 2-like protein) (HSF2-like) LOC392556 X similar to Melanoma-associated antigen 11 (MAGE-11 antigen) MAGEA11 Xq28 melanoma antigen, family A, 11 MAGEA9 Xq28 melanoma antigen, family A, 9 MAGEA7 Xq28 melanoma antigen, family A, 7, pseudogene MAGEA8 Xq28 melanoma antigen, family A, 8 LOC389900 X similar to DKFZP586L0724 protein LOC389901 X similar to ATP-dependent DNA helicase II, 70 kDa subunit (Lupus Ku autoantigen protein p70) (Ku70) (70 kDa subunit of Ku antigen) (Thyroid-lupus autoantigen) (TLAA) (CTC box binding factor 75 kDa subunit) (CTCBF) (CTC75) CXorf6 Xq28 chromosome X open reading frame 6 MTM1 Xq28 myotubular myopathy 1 MTMR1 Xq28 myotubularin related protein 1 CD99L2 Xq28 CD99 antigen-like 2 HMGB3 Xq28 high-mobility group box 3 LOC392557 X similar to hypothetical protein GPR50 Xq28 G protein-coupled receptor 50 LOC286456 Xq28 similar to NGFI-A binding protein 1; NGFI-A-binding protein 1; EGR1 binding protein 1 LOC139135 Xq28 hypothetical protein LOC139135 TMG3 Xq28 transmembrane gamma-carboxyglutamic acid protein 3 FATE Xq28 transmembrane gamma-carboxyglutamic acid protein 3 LOC389902 X similar to Cyclic-nucleotide-gated olfactory channel (Cyclic-nucleotide-gated cation channel 2) (CNG channel 2) (CNG-2) (CNG2) (Aorta CNG channel) (RACNG) MAGEA4 Xq28 melanoma antigen, family A, 4 GABRE Xq28 gamma-aminobutyric acid (GABA) A receptor, epsilon LOC392558 X similar to 33K laminin receptor homolog - bovine
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    4 - 1824 35 315 - Rogner (1995)
    EXPRESSION
    Type
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Reproductivemale systemtestis    Homo sapiens
    cells
    SystemCellPubmedSpeciesStageRna symbol
    Reproductivespermatocyte Homo sapiens
    cell lineage
    cell lines many tumor cell lines (melanoma, lung, breast), esophageal tumor
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA4/MAGEA11
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in embryonal development and tumor transformation or aspects of tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in superficial bladder cancer
    tumoral     --over  
    in renal cell carcinoma
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerurinarybladder
    relevant target for immunotherapy or chemoimmunotherapy because its expression can be induced by chemotherapeutic drugs, in bladder cancer
    cancerurinarykidney
    as well as RAGE may well provide suitable targets for immunotherapy of renal cell carcinoma
    ANIMAL & CELL MODELS