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FLASH GENE
Symbol MAGEA6 contributors: npt/ - updated : 27-03-2006
HGNC name melanoma antigen family A, 6
HGNC id 6804
Location Xq28      Physical location : 151.867.244 - 151.870.814
Synonym name
  • MAGE-6 antigen
  • cancer/testis antigen family 1, member 6
  • MAGE3B antigen
  • Synonym symbol(s) MAGE6, MAG6, MAGE3B, MAGE-3b, CT1.6, MGC52297
    DNA
    TYPE functioning gene
    SPECIAL FEATURE component of a cluster
    STRUCTURE 3.57 kb     3 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    MAPPING cloned Y linked N status confirmed
    Physical map
    GABRQ Xq28 gamma-aminobutyric acid (GABA) receptor, theta TRAG3 Xq28 taxol resistance associated gene 3 MAGEA2b Xq28 melanoma antigen, family A, 2, copy b MAGEA12 Xq28 melanoma antigen, family A, 12 CSAGE Xq28 chondrosarcoma associated gene 1 MAGEA2 Xq28 melanoma antigen, family A, 2 LOC389903 X similar to Taxol resistant associated protein 3 (TRAG-3) MAGEA3 Xq28 melanoma antigen, family A, 3 MAGEA6 Xq28 melanoma antigen, family A, 6 psMAGEA Xq28 melanoma antigen pseudogene, family A CETN2 Xq28 centrin, EF-hand protein, 2 H105E3 Xq28 centrin, EF-hand protein, 2 ZNF185 Xq28 zinc finger protein 185 (LIM domain) PNMA5 Xq28 paraneoplastic antigen like 5 PNMA3 Xq28 paraneoplastic antigen MA3 MGC15827 Xq28 hypothetical protein MGC15827 MAGEA1 Xq28 melanoma antigen, family A, 1 (directs expression of antigen MZ2-E)
    RNA
    TRANSCRIPTS type messenger
    text two transcripts encode the same protein
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    3 - 1723 34 314 - -
    encoding the same protein as variant 2
    3 - 1787 34 314 - -
  • containing an additional segment in the 5' UTR, in the 2nd codon as compared to variant 1
  • encoding the same protein as variant 1
  • EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Digestivestomach   moderately
    Endocrineadrenal gland   highly
    Reproductivefemale systemplacenta  highly
     female systemuteruscervix moderately
     male systemtestis   
     male systemprostate  moderately
    Skin/Tegumentskin   predominantly
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Blood / hematopoieticbone marrow   
    cell lineage
    cell lines in many tumor cell lines (melanoma, lung, breast)
    fluid/secretion
    at STAGE
    physiological period pregnancy
    Text placenta
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • a MAGE domain
  • HOMOLOGY
    intraspecies homolog to MAGEA12/MAGEA2
    Homologene
    FAMILY
  • MAGE family
  • CATEGORY antigen
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • may play a role in tumor transformation or aspects of tumor progression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in primary breast cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS